The Multiscale Neuroanatomy Lab develops theories on how the cellular organisation of the human brain gives rise to complex functional dynamics. Our research program is inspired by working at the interface of microscopy, neuroimaging and computational modelling. We combine post mortem data (histology and transcriptomics) with in vivo imaging (structural and functional MRI, intracranial EEG) to construct multiscale models of the human brain. We hold a special focus on microstructure, as a sort of lynchpin between post mortem and in vivo datasets, and work towards identifying overarching principles of cytoarchitectural organisation, such as the existence of large-scale gradients.
The lab also studies the maturation of cytoarchitecture, connectivity and functional dynamics across early life. Developmental changes are profound and multi-factorial. We leverage these changes to assess the inter-relation between biological scales, and effectively test our multi-scale models of brain organisation. In addition, we aim to use our multiscale frameworks to better understand neurodevelopmental disorders.
We believe that state-of-the-art neuroanatomy should be incorporated into workflows across neuroscience, from clinical research to building artificial intelligence. To this end, the lab develops tools that support integration of histology with neuroimaging (eg: BigBrainWarp) and we generate atlases of cortical organisation.
For more information see https://multiscale-neuroanatomy.github.io/