Research on various protein misfolding diseases


The focus of our research is on the one hand to elucidate the molecular and cellular disease mechanisms of various protein misfolding diseases, with a focus on Alzheimer's disease and type 2 diabetes mellitus. To this end, we use a diverse repertoire, ranging from biochemical and cellular methods to in vivo studies. Here we can draw on a wide range of different methods, including histological analyses. The aim of this basical research is to understand which pathological changes could be the cause of a disease and how this could be utilized to possibly develop a new target for a therapy. On the other hand, the focus of the working group is on the development of a causally effective therapy against type 2 diabetes mellitus. This is funded by a grant of the BMBF (title: Development of drug candidates for a causal therapy of type 2 diabetes mellitus).

Research Topics

  • Protein misfolding diseases
  • Alzheimer’s disease
  • Type 2 diabetes mellitus
  • mouse model of protein misfolding diseases
  • disease modifying treatment options
  • cellular and molecular mechanism of diseases


Dr. Sarah Schemmert


Building 05.8v / Room 2018

+49 2461/61-9447


Dominik Honold, B. A. Sc.

Selected Publications

Last Modified: 31.01.2024