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Institute of Biological Information Processing
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Bio- and chemical sensors with enzymes and macrocycles and potentiometric sensors

Biochemical Sensor

We work on the development and study of properties of electrochemical multisensor systems with redox proteins, oxidoreductase enzymes, molecular macrocycles, and their nanostructures based on molecular assembly for simultaneous detection and monitoring of reactive oxygen species, ions, ion/molecular transport, and redox signaling in single cells, cellular systems, and tissues.

The research emphases are:

  1. Metalloporphyrins and related macrocycles and their supramolecular assemblies for electrochemical sensors and catalysis.
  2. Mechanisms of the electron transfer to the electrode surface (e.g., dynamics of the analyte coordination; structure of the intermediates; electron transfer constants).
  3. Miniaturization of the electrochemical sensors. The remarkable sensitivity of new nanomaterial-based sensors opens up the possibility of detecting small quantities of analytes with high temporal and spatial resolution and investigating biological pathways that cannot be measured by conventional methods. Charge transfer between electrocatalytic centre of enzymes and transducer, which can be facilitated by electrochemical mediators and nanoelectronic building blocks is of particular interest.
  4. Analytical sensors characterization and analysis in model solutions, cells, and cellular systems.

We utilizes electrochemical techniques as well as a variety of spectroscopic, analytical, and structural analysis techniques to accomplish these goals.


Additional Information


Dr. Youlia Mourzina

Tel.:  +49-2461-61-2364


Direct electrochemistry of cyt c and hydrogen peroxide biosensing on oleylamine- and citrate-stabilized gold nanostructures. E. Koposova et al., Sensors and Actuators B 207 (2015) 1045-1052.


New membrane material for thallium (I)-selective sensors based on arsenic glasses. Yu. Ermolenko et al., Sensors and Actuators B 207 (2015) 940-944.


Electrochemically induced Ostwald Ripening in Au/TiO2 Nanocomposite. X. Liu et al., Journal of Physical Chemistry C 119 (2015) 10336-10344.


A novel bioelectrochemical interface based on in situ synthesis of gold nanostructures on electrode surfaces and surface activation by Meerwein’s salt. A bioelectrochemical sensor for glucose determination. K. Nikolaev et al., Bioelectrochemistry 105 (2015) 34-43.


Chemiresistors based on ultrathin gold nanowires for sensing halides, pyridine and dopamine. I. Muratova et al., Sensors and Actuators B 232 (2016) 420-427.


On “resistance overpotential” caused by a potential drop along the ultrathin high aspect ratio gold nanowire electrodes in cyclic voltammetry. I. Muratova et al.  et al., J Solid State Electrochem (2016).


The influence of meso-substitution of the porphyrin ring on enhanced hydrogen evolution in a photochemical system. E. Koposova et al., Journal of Physical Chemistry C 20 (2016) 13873-13890.


Morphological properties and photoconductivity of self-assembled Sn/Co porphyrin nanostructures. E.A. Koposova et al., Rev.Adv.Mater.Sci. (RAMS) N ½, Vol.45 (2016) 15-19. Open access.