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PD Dr. Oliver H. Weiergräber

PositionGroup leader

Photo PD Dr. Oliver H. Weiergräber


Forschungszentrum Jülich
52425 Jülich

Phone: +49 2461 61-2028
Fax: +49 2461 61-9540

Research Interests

  • Structural biology of proteins
  • Molecular biology of cellular macroautophagy

Representative Publications

Krichel, C., Möckel, C., Schillinger, O., Huesgen, P.F., Sticht, H., Strodel, B., Weiergräber, O.H., Willbold, D., and Neudecker, P. (2019). Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site. Sci. Rep. 9, 14167.

Abdollahzadeh, I., Hendriks, J., Sanwald, J.L., Simons, I.M., Hoffmann, S., Weiergräber, O.H., Willbold, D., and Gensch, T. (2019). Autophagy-related proteins GABARAP and LC3B label structures of similar size but different shape in super-resolution imaging. Molecules 24, 1833.

Klinker, S., Stindt, S., Gremer, L., Bode, J.G., Gertzen, C.G.W., Gohlke, H., Weiergräber, O.H., Hoffmann, S., and Willbold, D. (2019). Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication. J. Biol. Chem. 294, 7388-7402.

Schwarten, M., Weiergräber, O.H., Petrović, D., Strodel, B., and Willbold, D. (2019). Structural studies of autophagy-related proteins. Methods Mol. Biol. 1880, 17-56.

Abdollahzadeh, I., Schwarten, M., Gensch, T., Willbold, D., and Weiergräber, O.H. (2017). The Atg8 family of proteins-modulating shape and functionality of autophagic membranes. Front. Genet. 8, 109.

Yerabham, A.S.K., Mas, P.J., Decker, C., Soares, D.C., Weiergräber, O.H., Nagel-Steger, L., Willbold, D., Hart, D.J., Bradshaw, N.J., Korth, C. (2017). A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations. J. Biol. Chem. 292, 6468-6477.

Weiergräber, O.H., Schwarten, M., Strodel, B., and Willbold, D. (2017). Investigating structure and dynamics of Atg8 family proteins. Methods Enzymol. 587, 115-142.

Dick, M., Weiergräber, O.H., Classen, T., Bisterfeld, C., Bramski, J., Gohlke, H., Pietruszka, J. (2016). Trading off stability against activity in extremophilic aldolases. Sci. Rep. 6, 17908.

Michel, M., Schwarten, M., Decker, C., Nagel-Steger, L., Willbold, D., and Weiergräber, O.H. (2015). The mammalian autophagy initiator complex contains 2 HORMA domain proteins. Autophagy 11, 2300-2308.

Ma, P., Schillinger, O., Schwarten, M., Lecher, J., Hartmann, R., Stoldt, M., Mohrlüder, J., Olubiyi, O., Strodel, B., Willbold, D., and Weiergräber, O.H. (2015). Conformational polymorphism in autophagy-related protein GATE-16. Biochemistry 54, 5469-5479.

Ma, P., Schwarten, M., Schneider, L., Boeske, A., Henke, N., Lisak, D., Weber, S., Mohrlüder, J., Stoldt, M., Strodel, B., Methner, A., Hoffmann, S., Weiergräber, O.H., and Willbold, D. (2013). Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications. J. Biol. Chem. 288, 37204-37215.

Granzin, J., Huang, Y., Topbas, C., Huang, W., Wu, Z., Misra, S., Hazen, S.L., Blanton, R.E., Lee, X., and Weiergräber, O.H. (2012). Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain. Acta Cryst. D68, 686-694.

Thielmann, Y., Weiergräber, O.H., Ma, P., Schwarten, M., Mohrlüder, J., and Willbold, D. (2009). Comparative modeling of human NSF reveals a possible binding mode of GABARAP and GATE-16. Proteins 77, 637-646.

Thielmann, Y., Weiergräber, O.H., Mohrlüder, J., and Willbold, D. (2009). Structural framework of the GABARAP-calreticulin interface - implications for substrate binding to endoplasmic reticulum chaperones. FEBS J. 276, 1140-1152.

Weiergräber, O.H., Stangler, T., Thielmann, Y., Mohrlüder, J., Wiesehan, K., and Willbold, D. (2008). Ligand binding mode of GABAA receptor-associated protein. J. Mol. Biol. 381, 1320-1331.

Weiergräber, O.H., Senin, I.I., Zernii, E.Y., Churumova, V.A., Kovaleva, N.A., Nazipova, A.A., Permyakov, S.E., Permyakov, E.A., Philippov, P.P., Granzin, J., and Koch, K.-W. (2006). Tuning of a neuronal calcium sensor. J. Biol. Chem. 281, 37594-37602.

Granzin, J., Eckhoff, A., and Weiergräber, O.H. (2006). Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters. J. Mol. Biol. 364, 799-809.

Weiergräber, O.H., Eckhoff, A., and Granzin, J. (2006). Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters. FEBS Lett. 580, 251-255.