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Analytical Ultracentrifugation

The technique of analytical ultracentrifugation (AUC) was developed by Svedberg and Lysholm in 1927 (1). With AUC one is able to determine molecular weight, shape and stoichiometry of macromolecules and macromolecular complexes. AUC is an absolute method not depending on standards for comparison. More: Analytical Ultracentrifugation …

Artikel 1

Fluorescence correlation spectroscopy (FCS)

FCS is a method to detect molecular parameters like e.g. diffusion time, diffusion coefficent. Threrefore FCS can be used to analyse interaction of molecules (Elson & Magde, 1974; Magde et al., 1974; overview: Schwille & Haustein, 2001). In Fluorescence Correlation Spectroscopy the fluctuation of the fluorescence intensity is recorded in a very small volume, i.e. in femtoliter range via a confocal optic system. More: Fluorescence correlation spectroscopy (FCS) …

NMR-Teaser

Protein structure elucidation with NMR spectroscopy

Extraordinary advances occurred during the last few years in structural biology by nuclear magnetic resonance (NMR) spectroscopy. The precision and accuracy of solution structures by NMR improved dramatically and the upper range of molecular weights accessible to NMR structure determination is still increasing. More: Protein structure elucidation with NMR spectroscopy …

SPR1

Surface Plasmon Resonance (SPR)

This optical method allows detection and characterization of the binding of biological molecules. More: Surface Plasmon Resonance (SPR) …

PD

In vitro selection by phage display techniques

Phage display technologies allow the identification of peptide ligands for a given target molecule out of a huge library of different peptides expressed on the surface of bacteriophages. More: In vitro selection by phage display techniques …

Proteinexpression

Expression and purification of recombinant proteins

Various biophysical methods require large amounts of recombinantly expressed and purified proteins. More: Expression and purification of recombinant proteins …


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