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Receptors and brain dysfunction

In neurological and psychiatric diseases such as epilepsy, hepatic encephalopathy, progressive supranuclear palsy, Alzheimer's or Parkinson's disease, we find characteristic changes in receptor densities and "receptor fingerprints", which are an important aspect of dysfunction in these diseases.

To understand the mechanisms behind these pathological changes, we not only analyse the expression levels of neurotransmitter receptors in brain tissue obtained from patients, but also the receptor architecture of animal models of human diseases such as receptor knock-out mice. Furthermore, we are also interested in the comparative analysis of receptor densities and the expression levels of their encoding genes in the human brain.

Receptor FingerprintsNeurological diseases are associated with changes in the density of different receptor types. Asterisks highlight significantly altered receptor densities.
Copyright: Modified according to Palomero-Gallagher et al. (2012) Epilepsia 53: 1987-1997 and Chiu et al. (2017) Alzheimer's Res Ther 9:28.