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Publikationsdatenbank 236 Datensätze gefunden  1 - 10nächsteEnde  gehen zum Datensatz: Die Suche hat 0.01 Sekunden gedauert. 
1.
OpenAccess [FZJ-2020-03204] Journal Article
et al
Impact of Cholesterol on the Stability of Monomeric and Dimeric Forms of the Translocator Protein TSPO: A Molecular Simulation Study
Molecules 25(18), 4299 - () [10.3390/molecules25184299]
The translocator protein (TSPO) is a transmembrane protein present across the three domains of life. Its functional quaternary structure consists of one or more subunits [...]
OpenAccess: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA); Volltext: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA);
ddc:540
2.
OpenAccess [FZJ-2020-03180] Journal Article
et al
Hybrid MM/CG Webserver: Automatic Set Up of Molecular Mechanics/Coarse-Grained Simulations for Human G Protein-Coupled Receptor/Ligand Complexes
Hybrid Molecular Mechanics/Coarse-Grained (MM/CG) simulations help predict ligand poses in human G protein-coupled receptors (hGPCRs), the most important protein superfamily for pharmacological applications. This approach allows the description of the ligand, the binding cavity, and the surrounding water molecules at atomistic resolution, while coarse-graining the rest of the receptor. [...]
OpenAccess: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA); Volltext: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA);
ddc:570
3.
OpenAccess [FZJ-2020-03121] Poster (Other)
et al
Design and Simulation of a high-resolution and high-sensitivity BrainPET insert for 7T MRI
NuklearMedizin 2020, LeipzigLeipzig, Germany, 6 Jul 2020 - 9 Jul 20202020-07-062020-07-09
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4.
OpenAccess [FZJ-2020-03006] Journal Article
et al
Effect of a multicomponent exercise intervention on brain metabolism: A randomized controlled trial on Alzheimer's pathology (Dementia‐MOVE)
BackgroundPhysical activity has shown a positive impact on aging and neurodegeneration and represents a possible treatment option in cognitive decline. However, its underlying mechanisms and influences on brain pathology remain unclear. [...]
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ddc:610
5.
[FZJ-2020-02905] Contribution to a conference proceedings/Contribution to a book
et al
Model-Driven Development Methodology Applied to Real-Time MEG Signal Preprocessing System Design
2017 European Modelling Symposium (EMS) : [Proceedings] - IEEE, 2017. - ISBN 978-1-5386-1410-5 - doi:10.1109/EMS.2017.16
2017 UKSim-AMSS 11th European Modelling Symposium (EMS), ManchesterManchester, United Kingdom, 20 Nov 2017 - 21 Nov 20172017-11-202017-11-21
IEEE 28-33 () [10.1109/EMS.2017.16]
Model-based system engineering (MBSE) provides a high-level environment and efficiently handles the ever-rising complexity of computation and control systems. We introduce a requirement-driven, model-based development methodology (RDD & MBD) for real-time computation systems based on vendor neutral specifications. [...]
6.
OpenAccess [FZJ-2020-02875] Journal Article
et al
Optimization of high-channel count, switch matrices for multinuclear, high-field MRI
PLOS ONE 15(8), e0237494 - () [10.1371/journal.pone.0237494]
Modern magnetic resonance imaging systems are equipped with a large number of receive connectors in order to optimally support a large field-of-view and/or high acceleration in parallel imaging using high-channel count, phased array coils. Given that the MR system is equipped with a limited number of digitizing receivers and in order to support operation of multinuclear coil arrays, these connectors need to be flexibly routed to the receiver outside the RF shielded examination room. [...]
OpenAccess: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA); Volltext: August 2020 Customer Statement- PAB306070 - Volltext herunterladenPDF Volltext herunterladenPDF (PDFA); August 2020 Invoice- PAB306070 - Volltext herunterladenPDF Volltext herunterladenPDF (PDFA);
ddc:610
7.
Embargoed OpenAccess [FZJ-2020-02791] Journal Article
et al
Requirement-driven model-based development methodology applied to the design of a real-time MEG data processing unit
The paper describes a multidisciplinary work that uses a model-based systems engineering method for developing real-time magnetoencephalography (MEG) signal processing. We introduce a requirement-driven, model-based development methodology (RDD and MBD) to provide a high-level environment and efficiently handle the complexity of computation and control systems. [...]
Published on 2020-05-08. Available in OpenAccess from 2021-05-08.: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA); Volltext: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA);
ddc:004
8.
OpenAccess [FZJ-2020-02696] Journal Article
et al
Invasive versus non‐invasive mapping of the motor cortex
Human brain mapping 41(14), 3970-3983 () [10.1002/hbm.25101]
Precise and comprehensive mapping of somatotopic representations in the motor cortex is clinically essential to achieve maximum resection of brain tumours whilst preserving motor function, especially since the current gold standard, that is, intraoperative direct cortical stimulation (DCS), holds limitations linked to the intraoperative setting such as time constraints or anatomical restrictions. Non‐invasive techniques are increasingly relevant with regard to pre‐operative risk‐assessment. [...]
OpenAccess: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA);
ddc:610
9.
OpenAccess [FZJ-2020-02677] Journal Article
et al
Bolus infusion scheme for the adjustment of steady state [11C]Flumazenil levels in the grey matter and in the blood plasma for neuroreceptor imaging
The use of hybrid PET/MR imaging facilitates the simultaneous investigation of challenge-related changes in ligand binding to neuroreceptors using PET, while concurrently measuring neuroactivation or blood flow with MRI. Having attained a steady state of the PET radiotracer using a bolus-infusion protocol, it is possible to observe alterations in ligand neuroreceptor binding through changes in distribution volumes. [...]
OpenAccess: Volltext herunterladenPDF; Volltext: Volltext herunterladenPDF Volltext herunterladenPDF (PDFA);
ddc:610
10.
OpenAccess [FZJ-2020-02658] Journal Article
et al
An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems
BackgroundIn addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. [...]
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ddc:610

Publikationsdatenbank : 236 Datensätze gefunden   1 - 10nächsteEnde  gehen zum Datensatz:
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