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Publications database 220 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
1.
OpenAccess [FZJ-2020-02677] Journal Article
et al
Bolus infusion scheme for the adjustment of steady state [11C]Flumazenil levels in the grey matter and in the blood plasma for neuroreceptor imaging
The use of hybrid PET/MR imaging facilitates the simultaneous investigation of challenge-related changes in ligand binding to neuroreceptors using PET, while concurrently measuring neuroactivation or blood flow with MRI. Having attained a steady state of the PET radiotracer using a bolus-infusion protocol, it is possible to observe alterations in ligand neuroreceptor binding through changes in distribution volumes. [...]
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ddc:610
2.
OpenAccess [FZJ-2020-02658] Journal Article
et al
An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems
BackgroundIn addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. [...]
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ddc:610
3.
4.
OpenAccess [FZJ-2020-02596] Journal Article
et al
High uptake of 68Ga-PSMA and 18F-DCFPyL in the peritumoral area of rat gliomas due to activated astrocytes
BackgroundRecent studies reported on high uptake of the PSMA ligands [68Ga]HBED-CC (68Ga-PSMA) and 18F-DCFPyL in cerebral gliomas. This study explores the regional uptake and cellular targets of 68Ga-PSMA and 18F-DCFPyL in three different rat glioma models.MethodsF98, 9 L, or U87 rat gliomas were implanted into the brains of 38 rats. [...]
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ddc:610
5.
OpenAccess [FZJ-2020-02595] Journal Article
et al
Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly
Recent studies suggest that Tyr-39 might play a critical role for both the normal function and the pathological dysfunction of α-synuclein (αS), an intrinsically disordered protein involved in Parkinson’s disease. We perform here a comparative analysis between the structural features of human αS and its Y39A, Y39F, and Y39L variants. [...]
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ddc:540
6.
OpenAccess [FZJ-2020-02533] Journal Article
et al
Quantitative genome-wide association study of six phenotypic subdomains identifies novel genome-wide significant variants in autism spectrum disorder.
Autism spectrum disorders (ASD) are highly heritable and are characterized by deficits in social communication and restricted and repetitive behaviors. Twin studies on phenotypic subdomains suggest a differing underlying genetic etiology. [...]
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ddc:610
7.
[FZJ-2020-01769] Journal Article
et al
Image-based Motion Correction for the Siemens hybrid-MR/BrainPET Scanner
NuklearMedizin 2019, BremenBremen, 3 Apr 2019 - 6 Apr 20192019-04-032019-04-06 Nuklearmedizin 58(2), 181-182 () [10.1055/s-0039-1683702]
ddc:610
8.
OpenAccess [FZJ-2020-01715] Journal Article
et al
Design, evaluation and comparison of endorectal coils for hybrid MR-PET imaging of the prostate
Prostate cancer is one of the most common cancers among men and its early detection is critical for its successful treatment. The use of multimodal imaging, such as MR-PET, is most advantageous as it is able to provide detailed information about the prostate. [...]
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ddc:530
9.
OpenAccess [FZJ-2020-01506] Journal Article
et al
Neural Correlates of Empathy in Boys With Early Onset Conduct Disorder
Background: A deficit in empathy has repeatedly been described in individuals with conduct disorder (CD), and in particular in those with callous unemotional traits. Until now, little is known about the neural basis of empathy in children and adolescents with early onset conduct disorder. [...]
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ddc:610
10.
OpenAccess [FZJ-2020-01448] Journal Article
et al
PET/MRI Radiomics in Patients With Brain Metastases
Although a variety of imaging modalities are used or currently being investigated for patients with brain tumors including brain metastases, clinical image interpretation to date uses only a fraction of the underlying complex, high-dimensional digital information from routinely acquired imaging data. The growing availability of high-performance computing allows the extraction of quantitative imaging features from medical images that are usually beyond human perception. [...]
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ddc:610

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