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Publications database 263 records found  1 - 10nextend  jump to record: Search took 0.03 seconds. 
1.
OpenAccess [FZJ-2021-03023] Journal Article
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Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1G93A Transgenic Mice
Neuroinflammation is a pathological hallmark of several neurodegenerative disorders and plays a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS). It has been implicated as driver of disease progression and is observed in ALS patients, as well as in the transgenic SOD1G93A mouse model. [...]
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2.
OpenAccess [FZJ-2021-02643] Journal Article
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Imaging the Pathophysiology of Essential Tremor—A Systematic Review
Background: The pathophysiology underlying essential tremor (ET) still is poorly understood. Recent research suggests a pivotal role of the cerebellum in tremor genesis, and an ongoing controversy remains as to whether ET constitutes a neurodegenerative disorder. [...]
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3.
OpenAccess [FZJ-2021-02535] Journal Article
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Common neurobiological correlates of resilience and personality traits within the triple resting-state brain networks assessed by 7-Tesla ultra-high field MRI
Despite numerous studies investigating resilience and personality trials, a paucity of information regarding their neurobiological commonalities at the level of the large resting-state networks (rsNWs) remains. Here we address this topic using the advantages of ultra-high-field (UHF) 7T-MRI, characterized by higher signal-to-noise ratio and increased sensitivity. [...]
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4.
OpenAccess [FZJ-2021-02285] Journal Article
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Iterative Restoration of the Fringe Phase (REFRASE) for QSM
In quantitative susceptibility mapping (QSM), reconstructed results can be critically biased by misinterpreted or missing phase data near the edges of the brain support originating from the non-local relationship between field and susceptibility. These data either have to be excluded or corrected before further processing can take place. [...]
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5.
OpenAccess [FZJ-2021-02158] Journal Article
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Lesion-Function Analysis from Multimodal Imaging and Normative Brain Atlases for Prediction of Cognitive Deficits in Glioma Patients
Cancers 13(10), 2373 - () [10.3390/cancers13102373]
Cognitive deficits are common in glioma patients following multimodality therapy, but the relative impact of different types and locations of treatment-related brain damage and recurrent tumors on cognition is not well understood. In 121 WHO Grade III/IV glioma patients, structural MRI, O-(2-[18F]fluoroethyl)-L-tyrosine FET-PET, and neuropsychological testing were performed at a median interval of 14 months (range, 1–214 months) after therapy initiation. [...]
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6.
OpenAccess [FZJ-2021-01629] Journal Article
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Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate
A wide homology between human and macaque striatum is often assumed as in both the striatum is involved in cognition, emotion and executive functions. However, differences in functional and structural organization between human and macaque striatum may reveal evolutionary divergence and shed light on human vulnerability to neuropsychiatric diseases. [...]
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7.
OpenAccess [FZJ-2021-01406] Journal Article
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A Linearized Fit Model for Robust Shape Parameterization of FET-PET TACs
The kinetic analysis of 18F -FET time-activity curves (TAC) can provide valuable diagnostic information in glioma patients. The analysis is most often limited to the average TAC over a large tissue volume and is normally assessed by visual inspection or by evaluating the time-to-peak and linear slope during the late uptake phase. [...]
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8.
OpenAccess [FZJ-2021-01341] Journal Article
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A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model
Molecules 26(6), 1590 - () [10.3390/molecules26061590]
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by selective neuronal death in the brain stem and spinal cord. The cause is unknown, but an increasing amount of evidence has firmly certified that neuroinflammation plays a key role in ALS pathogenesis. [...]
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9.
OpenAccess [FZJ-2021-01337] Journal Article
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Combined 18F-FET PET and diffusion kurtosis MRI in post-treatment glioblastoma: differentiation of true progression from treatment related changes
BackgroundRadiological differentiation of tumor progression (TPR) from treatment-related changes (TRC) in pretreated glioblastoma is crucial. This study aimed to explore the diagnostic value of diffusion kurtosis MRI combined with information derived from O-(2-[18F]-fluoroethyl)-l-tyrosine (18F-FET) PET for the differentiation of TPR from TRC in patients with pretreated glioblastoma.MethodsThirty-two patients with histomolecularly defined and pretreated glioblastoma suspected of having TPR were included in this retrospective study. [...]
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10.
OpenAccess [FZJ-2021-01226] Journal Article
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Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review
Human brain mapping 42(8), 2642-2671 () [10.1002/hbm.25388]
A large body of molecular and neurophysiological evidence connects synaptic plasticity to specific functions and energy metabolism in particular areas of the brain. Furthermore, altered plasticity and energy regulation has been associated with a number of neuropsychiatric disorders. [...]
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