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The scientific case for brain simulations

HBP scientists argue for brain simulators as “mathematical observatories” for neuroscience

Simulations of large-scale networks of neurons are a key element in the European Human Brain Project (HBP). In a new perspective article scientists from the HBP argue why such simulations are indispensable for bridging the scales between the neuron and system levels in the brain. The authors describe the need for open general-purpose simulation engines that can run a multitude of different candidate models of the brain at different levels of biological detail. Comparing predictions derived from such simulations with experimental data will allow systematic testing and refinement of models in a loop between computational and experimental neuroscience.

The article has been published as a featured perspective in the leading journal Neuron and can be read here.

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