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Institute of Bio- and Geosciences IBG-1: Biotechnology

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Microfluidic single-cell analysis

Microfluidic chip

Microfluidic chip cultivation technology combining several hundred multiplexed picolitre-bioreactors with time-lapse microscopy for automated growth and morphology analysis at single-cell level.

Selected publications:

  • Grünberger A, Schöler K, Probst C, Kornfeld G, Hardiman T, Wiechert W, Kohlheyer D & Noack S (2017): Real-time monitoring of fungal growth and morphogenesis at single-cell resolution. Eng Life Sci
  • Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D & Noack S (2014): Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnol Bioeng
  • Grünberger A, van Ooyen J, Paczia N, Rohe P, Schendzielorz G, Eggeling L, Wiechert W, Kohlheyer D & Noack S (2013): Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. Biotechnol Bioeng
  • Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W & Kohlheyer D (2012): A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab Chip

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