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Institute of Bio- and Geosciences IBG-1: Biotechnology

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Metabolic flux analysis


Targeted, quantitative fluxomics based on ultra-fast (3 Hz) bioreactor sampling technologies for transient labeling experiments and in-house software (13CFLUX2) for model-based flux estimation.

Selected publications:

  • Kappelmann J, Wiechert W & Noack S (2016): Cutting the Gordian knot: Identifiability of anaplerotic reactions in Corynebacterium glutamicum by means of 13C metabolic flux analysis. Biotechnol Bioeng
  • Hanke T, Nöh K, Noack S, Polen T, Bringer-Meyer S, Sahm H, Wiechert W & Bott M (2013): Combined fluxomics and transcriptomics analysis of glucose catabolism via partially cyclic pentose phosphate pathway in Gluconobacter oxydans 621H. Appl Environ Microbiol
  • Beste DJV, Bonde B, Hawkins N, Wards JL, Beale MH, Noack S, Nöh K, Kruger NJ, Ratcliffe RG & McFadden J (2011): 13C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobateria which requires isocitrate lyase and carbon dioxide fixation. PLoS Pathog
  • Bartek T, Blombach B, Lang S, Eikamnns BJ, Wiechert W, Oldiges M, Nöh K & Noack S (2011): Comparative 13C-metabolic flux analysis of PDHC-deficient L-valine producing Corynebacterium glutamicum. Appl Environ Microbiol
  • Noack S, Nöh K, Moch M, Oldiges M & Wiechert W (2011): Stationary versus non-stationary 13C-MFA: A comparison using a consistent dataset. J Biotechnol