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Institute of Bio- and Geosciences IBG-1: Biotechnology

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Mini Pilot Plant


  • Mini Pilot Plants integrating lab robotics and the BioLector technology for miniaturized and automated cultivation experiments.
  • Powerful robotic workflows and high-throughput assays for standard and tailor-made bioprocess optimization.



Selected publications

  • Morschett H, Schiprowski D, Müller C, Mertens K, Felden P, Meyer J, Wiechert W & Oldiges M (2017): Design and validation of a parallelized micro-photobioreactor enabling phototrophic bioprocess developmenz and elevated throughput. Biotechnol Bioeng
  • Morschett H, Schiprowski D, Rohde J, Wiechert W & Oldiges M (2017): Comparative evaluation of phototrophic microtiter plate cultivation against laboratory-scale photobioreactors. Bioproc Biosys Eng
  • Morschett H, Freier L, Rohde J, Wiechert W, von Lieres E & Oldiges M (2017): A framework for accelerated phototrophic bioprocess development: integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design. Biotechnol Biofuels
  • Radek A, Müller MF, Gätgens J, Eggeling L, Krumbach K, Marienhagen J & Noack S (2016): Formation of xylitol and xylitol-5-phosphate and its impact on growth of D-xylose-utilizing Corynebacterium glutamicum. J Biotechnol
  • Morschett H, Wiechert W & Oldiges M (2016): Automation of a Nile red staining assay enables high throughput quantification of microalgal lipid production. Microb Cell Fact
  • Hemmerich J, Rohe P, Kleine B, Jurischka SK, Wiechert W, Freudl R & Oldiges M (2016): Use of a Sec signal peptide library from Bacillus subtilis for the optimization of cutinase secretion in Corynebacterium glutamicum. Microb Cell Fact
  • Unthan S, Radek A, Wiechert W, Oldiges M & Noack S (2015): Bioprocess automation on a Mini Pilot Plant enables fast quantitative microbial phenotyping. Microb Cell Fact
  • Unthan S, Baumgart M, Radek A, Herbst M, Siebert D, Brühl N, Bartsch A, Bott M, Wiechert W, Marin K, Hans S, Krämer R, Seibold G, Frunzke J, Kalinowski J, Rückert C, Wendisch VW & Noack S (2015): Top-down towards a chassis organism - Identification and deletion of irrelevant gene clusters from Corynebacterium glutamicum. Biotechnol J
  • Rohe P, Venkenna D, Kleine B, Freudl R & Oldiges M (2012): An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform. Microb Cell Fact