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Hybrid MR-PET imaging combines the advantages of both imaging techniques. This challenging task is met by one team joining scientists with different backgrounds including MR, PET and neuroncology.

At present, a new hybrid imaging technology combining PET and MRI is emerging. The construction of hybrid scanners that allow simultaneous MRI and PET required the development of a new type of MR-compatible PET detector, which was first realized for studying small animals. The first industrial prototypes of such integrated MR-PET scanners for human brain studies have been installed recently. Beyond time saving in patient management and optimal spatial overlay of anatomic and functional information, this technique offers new perspectives with regard to the simultaneous observation of physiological and biochemical processes. Functional brain activation and interaction of receptor ligands during special activation tasks or pharmacological intervention may be explored in humans. Thus, MR-PET opens new horizons in multiparametric neuroimaging.

The institute holds two hybrid MR-PET scanners at high field and ultra high field with 3 Tesla and 9.4 Tesla, respectively. Both scanners are based on whole body Siemens-Medical MRI systems equipped with identical Siemens BrainPET inserts. The PET inserts are based on Avalanche photo diodes since conventional photo multipliers are not working inside the magnetic field of the MR-scanners. The positioning of the BrainPET insert in the centre of the magnet offers the opportunity for iso-centred imaging in space and time.

Trimodal imaging in one session: FET-PET, MP-RAGE and DTI in humans

Trimodal Imaging in one Session: FET-PET, MP-RAGE and DTI in Humans

The acquisition of trimodal PET, MP-RAGE and DTI data on an MR-PET hybrid scanner, capable of simultaneous MR and PET, to investigate plasticity and reorganisation in human brain tumours is demonstrated.

Clinical protocol for brain tumour patients using Hybrid MR-BrainPET

Clinical MR-PET

This study demonstrates how a versatile multimodal protocol can be performed in a routine clinical set up of approximately 45 minutes scanning time acquiring PET and MR data simultaneously.

Arterial Spin Labling

Arterial Spin Labling

Our aim is to develop and validate the ASL techniques for different MR-PET applications.

MRI Spectroscopy

MRI Spectroscopy

MRI Spectroscopy is a technique that provides biochemical information about the tissues of the human body in a non-invasive way. It can be used for brain physiology research.

Additional Information


Project Leader

Prof. N. J. Shah, PhD


Dr. Liliana Caldeira

Dr. Jörg Mauler

Prof. Irene Neuner, MD









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