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Institute of Neuroscience and Medicine

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Sequence Development

The sequence development team deals with the design of new Magnetic Resonance Imaging (MRI) techniques tailored to neuroscientific applications. MRI sequences drive the magnetic fields to manipulate the spin system with the aim of generating high contrast images of tissue in short scan times. To achieve these goals, a detailed knowledge of the underlying MRI physics as well as excellent computer programming skills are required. One of the major current research areas is the acquisition of high quality MRI brain images at ultra-high magnetic field strengths (9.4 Tesla). In addition to the team's principal field of research, the team members contribute methodological input to several research projects with internal and external partners.


Fast Multi-channel Excitation Mapping

Fast Multi-channel Excitation Field Mapping

Spatial inhomogeneities of the excitation radio frequency field are a major source of image artefacts, especially at ultra-high field strengths (> 3T).

Unique and Flexible Isotropic Diffusion Encoding

Unique and Flexible Isotropic Diffusion Encoding

Extensively precomputed diffusion-weighting direction schemes are usually used for diffusion imaging with a restricted number of directions. Our analytical approach facilitates a more flexible experimental planning

Elements of the jemris user interfaces.


MRI simulations are needed in many cases and deliver many advantages over real systems. The development of new ideas as well as the optimization of known protocols are supported by MRI simulations.

Sample 2D excitation

Parallel Transmit Pulse Design

Selective excitation of an arbitrary 3D target region requires long high frequency pulses, which can be considerably shortened by means of multiple transmit channels. This project investigates new approaches for the numerically demanding calculation of the pulseshapes, in order to apply 3D selective excitation in routine applications.

Simulation of the High Field BOLD Signal

Simulation of the High Field BOLD Signal

Most functional MR images rely on the blood oxygenation level dependent (BOLD) MR signal. The physiological origin of this signal, which depends on variables such as the cerebral blood volume (CBV), the cerebral blood flow (CBF) and cerebral metabolic rate of oxygen(CMRO2), is still not completely known and are an active field of research and debate. The aim of this project is the simulation of the BOLD MR signal using the general purpose MR simulator JEMRI

Additional Information

Sequence Development

Project Leader

Prof. N. J. Shah, PhD


Ivan Maximov, PhD

Sandro Romanzetti, PhD

Nuno da Silva, MSc

Seong Dae Yun, PhD

Ke Zhang, PhD