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Institute of Neuroscience and Medicine

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Technical Aspects of MR-PET

The hybrid scanner 3TMR-PET consists of a high resolution BrainPET, newly constructed by Siemens, and a commercial 3T MAGNETOM Trio MRI scanner. The 9.4TMR-PET combines the BrainPET with a 9.4TMRI developed through collaboration between the Forschungszentrum Juelich and Siemens. The BrainPET is a compact cylinder with a length of 72 cm and an outer diameter of 60 cm fitting snugly into bore of the magnets. Within its inner diameter of 32 cm there is a birdcage head coil used for both transmitting radiofrequency pulses and receiving the signals and an inner 8-channel coil for receive only. The BrainPET consists of 32 copper shielded cassettes each containing 6 detector modules covering an axial field-of-view (FOV) of 19.2 cm. The front end of the detector module is a 12 x 12 matrix of 2.5 x 2.5 x 20 mm3 individual LSO (Lutetium oxysilicate)scintillation crystals coupled to a 3 x 3 array of Avalanche photodiodes (APD). The APD are not influenced by the magnetic field and are used instead of photomultipliers which would not work in the MR environment. Since the APDs are temperature sensitive, the temperature of the BrainPET is stabilized with cooled air. The APD output signals are preamplified and transferred via long cables to the filter plate, and thereafter to the data acquisition electronics. Here the coincidence lines are recorded so that PET images can be reconstructed as decribed at ( Technical Aspects of Positron-Emission-Tomography). The BrainPET offers an excellent image resolution of 3 mm at the centre.

Projects

Schwächungskorrekturen für MR-PET

Attenuation Correction for MR-PET

Present hybrid MR-PET scanners, which allow simultaneous imaging of both modalities, do not offer transmission scans for a PET-based measured attenuation correction

Quantitative PET Imaging in MRPET

Quantitative PET imaging with MR-PET

PET images are, however, not only expected to be of high quality, but should produce quantitative data of metabolic functions. To achieve this aim we developed and implemented methods to quantify the PET images that are acquired simultaneously with MRI.

Entwicklung iterativer Rekonstruktionsmethoden

Development of iterativer reconstruction methods

PET images reconstructed by iterative methods such as the maximum likelihood expectation maximisation (MLEM) or ordered subset expectation maximisation (OSEM) algorithms exhibit a favourable signal-to-noise ratio compared to results of filtered back projection, especially in the case of studies with low counts.

Entwicklung und Optimierung von MRPET-Anwendungen

Development and optimisation of MR-PET applications

Dynamic PET studies such as those performed in brain tumour patients after injection of [18F]-Fluor-Ethyl-Tyrosine (FET) last for 50 minutes. During this period a number of MR sequences can be performed.

Additional Information

MR-PET

Team Leader

Dr. Christoph Lerche

Members

Silke French

Konny Frey

Dr. Elena Rota Kops

Suzanne Schaden

Dr. Jürgen Scheins

Liesel TheelenLutz Tellmann



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