Mechanobiology (IBI-2)
The research of IBI-2 aims at an in-depth understanding of information processing by living cells. They communicate, that is they exchange information, via chemical and physical signals. In our experiments we focus on generation, sensing and processing of mechanical signals such as forces, stiffness and topography by cells of the central nervous system. We are especially interested in the interplay of cellular architecture and mechanical properties, in the interactions of cells with their environment, that is with the extracellular matrix or neighboring cells, as well as in sensing and processing of mechanical signals by cells. These questions are vital for many physiological and pathological processes like embryonal development, cancer progression and concussion. In this quest, we use and, if needed, develop cutting-edge tools of cell biophysics and cell biology. Our final goal is to contribute from basic science to knowledge-based methods of diagnosis, prevention and treatment in medicine.