Abhishek Arun Cukkemane

Dr. Abhishek Arun Cukkemane

Research Topics

Protein Crystallography, Solid-state NMR spectroscopy, Biophysics, Biochemistry, NMR-metabolomics


Structural Biochemistry

Room No 2019

Forschungszentrum Jülich

D-52425 Juelich

Institute of Biological Information Processing (IBI)

Structural Biochemistry (IBI-7)

Building 05.8v / Room 2019

You can find us here

Welcome to the research group of “The Unmelodramatics”

Hey There,

I am Abhishek and my group’s research activities revolve around comprehending the molecular basis of the psychiatric disorder schizophrenia.

We are studying the the influence of protein risk-fators using a variety of structural biology tools such as X-ray crystallography, solid-state NMR spectroscopy and electron microscopy to comprehend the 3D architecture of the schizophrenia protein risk factor called Disrupted-in-schizophrenia-1 (DISC1); at the same time we are combining bio-physical tools such as iso-thermal titration calorimetry and dynamic light scattering to study the thermodynamics and kinetics of DISC1 aggregation; and surface-plasmon resonance and bio-layer interferometry to study the interaction of DISC1 with other relevant risk factors namely the NUDEL proteins and Lis1.

Also, we are biochemically profiling the biological fluids from schizophrenia patients to comprehend the metabolites and pathways that are critical for identifying patients suffering from the schizophrenia. For which, we are performing qNMR metabolomics studies at the BioNMR facility in the campis and combining it with big data analytics. In latter stages we will employ ML techniques to improve the quality of predictions of the relevant biomarkers.

Last Modified: 04.09.2023