Dr. Alexandros Katranidis

Contact

+49 2461/61-85474

+49 2461/61-1448

E-Mail

ORCID: 0000-0002-1785-1659

Publons: J-3546-2013

Research Gate

Address

Forschungszentrum Jülich GmbH
Wilhelm-Johnen-Straße
52428 Jülich

Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C)

Structural Biology (ER-C-3)

Building 05.2 / Room 4008

You can find us here

About me

I studied Chemistry with a focus on Biochemistry and Molecular Biology and later obtained a Master’s degree in Nanobiotechnology from Aristotle University of Thessaloniki, Greece. For my PhD I moved to the Forschungszentrum Jülich in the group of Georg Büldt, where I studied protein folding on the ribosome, spending also time in the lab of Knud Nierhaus at the MPI for Molecular Genetics in Berlin. After obtaining my PhD I remained at the Forschungszentrum Jülich in the group of Jörg Fitter as a postdoc and later as a Project Leader, continuing to work on co-translational protein folding using single molecule fluorescence methods. During this time, I established different cell-free protein synthesis systems, as well as the incorporation of unnatural amino acids into proteins. In parallel, I initiated collaborations with the labs of Martin Hegner at Trinity College in Dublin and Sander Tans at AMOLF in Amsterdam, both experts in Optical Tweezers, a force-based single molecule technique.

Joining the Sachse lab my intention is to bring and combine my previous acquired knowledge with structural biology and cryoEM.

Vita

Since 01.2022

Staff member at ER-C-3 / IBI-6 of Forschungszentrum Jülich

Carsten Sachse group

10.2010 – 12.2021

Project leader at IBI-6 (former ICS-5) of Forschungszentrum Jülich

Single molecule biophysics

Jörg Fitter group

'Co-translational protein folding' and 'Incorporation of unnatural aminoacids into proteins'

02.2009 – 09.2010

Postdoc at ISB-2 of Forschungszentrum Jülich

Georg Büldt group

05.2005 – 02.2009

Doctoral thesis in Nanobiotechnology

Experimental work at ISB-2 of Forschungszentrum Jülich

‘Studies on protein synthesis using Optical Tweezers and single molecule FRET’

Georg Büldt group

09.2004 – 05.2005

Master Thesis in Nanobiotechnology

Biochemistry department at Aristotle University of Thessaloniki

‘In vivo and in vitro labeling of ribosomes for further studies using Optical Tweezers’

Choli-Papadopoulou group

Publications

Selected Publications

For a full list of publications check ORCID: 0000-0002-1785-1659

Wruck, F., Tian, P., Kudva, R., Best, R.B., von Heijne, G., Tans, S.J. and Katranidis, A*. The ribosome modulates folding inside the ribosomal exit tunnel Commun. Biol. (2021) *corresponding author

Höfig, H., Yukhnovets, O., Remes, C., Kempf, N., Katranidis, A., Kempe, D. and Fitter, J. Brightness-Gated Two-Color Coincidence Detection Unravels Two Distinct Mechanisms in Bacterial Protein Translation Initiation Commun. Biol. (2019)

Katranidis, A*. and Fitter, J. Single-molecule techniques and cell-free protein synthesis: a perfect marriage Anal. Chem. (2019) *corresponding author

Sadoine, M., Cerminara, M., Gerrits, M., Fitter, J. and Katranidis, A*. Cotranslational Incorporation into Proteins of a Fluorophore Suitable for smFRET Studies ACS Synth. Biol. (2018) *corresponding author

Sadoine, M., Cerminara, M., Kempf, N., Gerrits, M., Fitter, J. and Katranidis, A*. Selective double-labeling of cell-free synthesized proteins for more accurate smFRET studies Anal. Chem. (2017) *corresponding author

Wruck, F., Katranidis, A^*., Nierhaus, K.H., Büldt, G. and Hegner, M. Translation and folding of single proteins in real time PNAS (2017) *corresponding author

Kempf, N., Remes, C., Ledesch, R., Züchner, T., Höfig, H., Ritter, I., Katranidis, A^*. and Fitter, J. A novel method to evaluate ribosomal performance in cell-free protein synthesis systems
Sci. Rep. (2017) *corresponding author

Katranidis, A., Atta, D., Schlesinger, R., Nierhaus, K.H., Choli-Papadopoulou, T., Gregor, I., Gerrits, M., Büldt, G. and Fitter, J. Fast Biosynthesis of GFP Molecules: A Single-Molecule Fluorescence Study Angew. Chem. (2009)

Last Modified: 04.11.2025