Dr.-Ing. Stephan Noack

2010 – Group leader “Quantitative Microbial Phenotyping”, Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, Germany

2014 Visiting scientist, Novo Nordisk Foundation Center for Biosustainability, Hørsholm, Denmark

2009 – 2010 Postdoctoral fellow in “Fermentation Technology" group, Institute of Biotechnology, Forschungszentrum Jülich, Germany

2009 Dr.-Ing. University of Siegen, Thesis title: “Integrative evaluation of multi-omics data of the central metabolism of Corynebacterium glutamicum”

2005 – 2009 PhD-Thesis work under supervision of Prof. Dr. Wolfgang Wiechert, Institute of Biotechnology 2, Forschungszentrum Jülich, Germany

2000 – 2005 Master of Bioprocess Engineering, Technical University of Dresden, Dresden, Germany, Thesis title: “Visualization and analysis of biochemical network models”

Key Research Activities

· Automation technologies for targeted and untargeted strain engineering

· Quantitative omics analytics for metabolic and bioprocess modelling

· Synthetic mixed cell cultures based on streamlined genomes

· Microbial upcycling of plant-based feedstock for monomer production

Selected Activities and Memberships

2021 – Editorial Board of Current Opinion in Biotechnology

2021 – Editorial Board of Microbial Cell Factories

2018 – 2021 Coordinator of BioSC FocusLab-Projekt „HyImPAct“

2015 – Co-manager of „Jülich Microbial Phenotyping Center“

2016 – 2019 Co-coordinator of Helmholtz Innovation Lab „MiBioLab

2018 – Member of „Systems Biology and Synthetic Biology“ of DECHEMA e.V.

2016 – Editorial Board of Scientific Reports

2015 – 2019 Coordinator of ERASysAPP-Projekt „XyloCut“

2012 – Editorial Board of Engineering in Life Sciences

2011 – 2016 Member of the “Zukunftsforum Biotechnologie” of DECHEMA e.V.

Honors and Awards

2019 Supervision Award of BioEconomy Science Center

2019 Labvolution Award for Microbial BioProcess Lab

2018 Innovation Plus Award of Forschungszentrum Jülich

2007 Karl-Schügerl Research Award of Biotechnology

Selected Publications

1) Tenhaef N, Stella R, Frunzke J, Noack S (2021). Automated Rational Strain Construction Based on High-Throughput Conjugation. ACS Synth Biol, 10(3), 589-599

2) Stella RG, Gertzen CG, Smits SH, Gätgens C, Polen T, Noack S, Frunzke J (2021). Biosensor-based growth-coupling and spatial separation as an evolution strategy to improve small molecule production of Corynebacterium glutamicum. Metab Eng, 68, 162-173

3) Burmeister B, Akhtar Q, Hollmann L, Tenhaef N, Sokolowsky S, Marienhagen M, Noack S, Kohlheyer K, Grünberger A (2021) (Optogenetic) control of synthetic microbial co-culture interactions on single-cell level. ACS Synth Biol 10(6):1308–1319

4) Kappelmann J, Klein B, Papenfuß M, Lange J, Blombach B, Takors R, Wiechert W, Polen T, Noack S (2021). Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions. Front Bioeng Biotechnol 8, 1549

5) Khushboo Borah K, Mendum TA, Hawkins ND, Ward JL, Beale MH, Larrouy-Maumus G, Bhatt A, Moulin M, Haertlein M, Strohmeier G, Pichler H, Forsyth VT, Noack S, Goulding CW, Mc-Fadden J, Beste DJV (2021) Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis. Mol Syst Biol 17(5):e10280

6) David JR, Noack S (2020) Editorial overview: Causes and biotechnological application of microbial metabolic specialization. Curr Opin Biotechnol 62

7) Noack S, Baumgart M (2019). Communities of Niche-Optimized Strains: Small-genome organism consortia in bioproduction. Trends Biotechnol. 37, 126-139.

8) Burmeister A, Hilgers F, Langner A, Westerwalbesloh C, Kerkhoff Y, Tenhaef N, Drepper T, Kohlheyer D, von Lieres E, Noack S, Grünberger A (2019). A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments. Lab Chip. 19, 98-110.

9) Kappelmann J, Beyss M, Nöh K, Noack S (2019) Separation of ¹³C- and ¹⁵N-Isotopologues of Amino Acids with a Primary Amine without Mass Resolution by Means of O-Phthalaldehyde Derivatization and Collision Induced Dissociation. Anal Chem 2019, 91 (21), 13407-13417.

10) Baumgart M, Unthan S, Kloß R, Radek A, Polen T, Tenhaef N, Müller MF, Küberl A, Siebert D, Brühl N, Marin K, Hans S, Krämer R, Bott M, Kalinowski J, Wiechert W, Seibold G, Frunzke J, Rückert C, Wendisch VF, Noack S (2018). Corynebacterium glutamicum chassis C1*: building and testing a novel platform host for synthetic biology and industrial biotechnology. ACS Synth Biol. 7, 132-144.

11) Kappelmann J, Klein B, Geilenkirchen P, Noack S (2017). Comprehensive and accurate tracking of carbon origin of LC-tandem mass spectrometry collisional fragments for ¹³C-MFA. Anal Bioanal Chem. 409, 2309-2326.

12) Radek A, Tenhaef N, Müller MF, Brüsseler C, Wiechert W, Marienhagen J, Polen T, Noack S (2017) Miniaturized and automated adaptive laboratory evolution: Evolving Corynebacterium glutamicum towards an improved d-xylose utilization. Bioresour Technol 245(Pt B):1377-1385