Dr. Erik Noetzel-Reiss

Since 2017 Principle investigator at the Institute of Information Processing (IBI), IBI-2: Biomechanics: Forschungszentrum Jülich GmbH, Germany

2012-2016 Postdoc, Institute of Complex Systems (ICS-7): Biomechanics: Forschungszentrum Jülich GmbH, Germany

2011 Postdoc, Institute of Pathology, Medical Faculty of RWTH Aachen University, Germany

2007-2010 Doctoral researcher, Institute of Pathology, Medical Faculty of RWTH Aachen University, Germany, Graduation with Distinction.

2001-2006 Study of Biology at the RWTH University Aachen, Diploma in Molecular Cell Biology, Genetics, Microbiology and Protein Chemistry.

1. Azarkh, D., Geiger, M., Jung, S.-H., Noetzel, E., Merkel, R., Pich, A. & Schnakenberg, U. Characterization of transient rheological behavior of soft materials using ferrofluid droplets. Sensors and Actuators A: Physical 344, 113756 (2022). https://doi.org/10.1016/j.sna.2022.113756

2. Friedland, F., Babu, S., Springer, R., Konrad, J., Herfs, Y., Gerlach, S., . . . Noetzel, E. ECM-transmitted shear stress induces apoptotic cell extrusion in early breast gland development. Front Cell Dev Biol 10, 947430 (2022). 10.3389/fcell.2022.947430

3. Eschenbruch, J., Dreissen, G., Springer, R., Konrad, J., Merkel, R., Hoffmann, B. & Noetzel, E. From Microspikes to Stress Fibers: Actin Remodeling in Breast Acini Drives Myosin II-Mediated Basement Membrane Invasion. Cells 10 (2021). 10.3390/cells10081979

4. Rose, M., Noetzel, E., Kistermann, J., Eschenbruch, J., Rushrush, S., Gan, L., . . . Dahl, E. The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells. Cells 10 (2021). 10.3390/cells10051038

5. Gaiko-Shcherbak, A., Eschenbruch, J., Kronenberg, N.M., Teske, M., Wolters, B., Springer, R., . . . Noetzel, E. Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini. Int J Mol Sci 22 (2021). 10.3390/ijms22083962

6. Wiedenhoeft, T., Braun, T., Springer, R., Teske, M., Noetzel, E., Merkel, R. & Csiszar, A. The Basement Membrane in a 3D Breast Acini Model Modulates Delivery and Anti-Proliferative Effects of Liposomal Anthracyclines. Pharmaceuticals (Basel) 13 (2020). 10.3390/ph13090256

7. Fabris, G., Lucantonio, A., Hampe, N., Noetzel, E., Hoffmann, B., DeSimone, A. & Merkel, R. Nanoscale Topography and Poroelastic Properties of Model Tissue Breast Gland Basement Membranes. Biophys J 115, 1770-1782 (2018). 10.1016/j.bpj.2018.09.020

8. Schlensog, M., Magnus, L., Heide, T., Eschenbruch, J., Steib, F., Tator, M., Kloten, V., Rose, M., Noetzel, E., Gaisa, N.T., Knuchel, R. & Dahl, E. Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients. Epigenetics 13, 214-227 (2018). 10.1080/15592294.2016.1229730

9. Rose, M., Kloten, V., Noetzel, E., Gola, L., Ehling, J., Heide, T., . . . Dahl, E. ITIH5 mediates epigenetic reprogramming of breast cancer cells. Mol Cancer 16, 44 (2017). 10.1186/s12943-017-0610-2

10. Gaiko-Shcherbak, A., Fabris, G., Dreissen, G., Merkel, R., Hoffmann, B. & Noetzel, E. The Acinar Cage: Basement Membranes Determine Molecule Exchange and Mechanical Stability of Human Breast Cell Acini. PLoS One 10, e0145174 (2015). 10.1371/journal.pone.0145174

11. Serce, N.B., Boesl, A., Klaman, I., von Serenyi, S., Noetzel, E., Press, M.F., . . . Dahl, E. Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis. BMC Cancer 12, 597 (2012). 10.1186/1471-2407-12-597

12. Noetzel, E., Rose, M., Bornemann, J., Gajewski, M., Knuchel, R. & Dahl, E. Nuclear transport receptor karyopherin-alpha2 promotes malignant breast cancer phenotypes in vitro. Oncogene 31, 2101-2114 (2012). 10.1038/onc.2011.403

13. Noetzel, E., Rose, M., Sevinc, E., Hilgers, R.D., Hartmann, A., Naami, A., . . . Dahl, E. Intermediate filament dynamics and breast cancer: aberrant promoter methylation of the Synemin gene is associated with early tumor relapse. Oncogene 29, 4814-4825 (2010). 10.1038/onc.2010.229

14. Verjans, E., Noetzel, E., Bektas, N., Schutz, A.K., Lue, H., Lennartz, B., . . . Bernhagen, J. Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer 9, 230 (2009). 10.1186/1471-2407-9-230

15. Veeck, J., Noetzel, E., Bektas, N., Jost, E., Hartmann, A., Knuchel, R. & Dahl, E. Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer. Mol Cancer 7, 83 (2008). 10.1186/1476-4598-7-83

16. Noetzel, E., Veeck, J., Horn, F., Hartmann, A., Knuchel, R. & Dahl, E. [Promoter methylation of ID4. A marker for recurrence-free survival in human breast cancer]. Pathologe 29 Suppl 2, 319-327 (2008). 10.1007/s00292-008-1038-7

17. Noetzel, E., Veeck, J., Niederacher, D., Galm, O., Horn, F., Hartmann, A., . . . Dahl, E. Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer. BMC Cancer 8, 154 (2008). 10.1186/1471-2407-8-154

18. Veeck, J., Geisler, C., Noetzel, E., Alkaya, S., Hartmann, A., Knuchel, R. & Dahl, E. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis 29, 991-998 (2008). 10.1093/carcin/bgn076

19. Bektas, N., Noetzel, E., Veeck, J., Press, M.F., Kristiansen, G., Naami, A., . . . Dahl, E. The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer. Breast Cancer Res 10, R58 (2008). 10.1186/bcr2117