Agnes Csiszar

Dr. Agnes Csiszar

Senior Scientist


Lipid-based nanoparticles, Molecular drug delivery, Cell membrane engineering, Model biomembranes


+49 2461/61-1415

+49 2461/61-3907


ORCID 0000-0002-8901-6804


Forschungszentrum Jülich GmbH
Wilhelm-Johnen Str.
52428 Jülich

Institut für Biologische Informationsprozesse (IBI)

Mechanobiologie (IBI-2)

Gebäude 02.4 / Raum R 336

New strategy for breaking the cellular membrane barriers

Delivery of biomolecules to mammalian cells is a crucial step in all pharmacological treatments and most life sciences applications. Lipid nanoparticles or liposomes are frequently used for this purpose based on their high bioavailability and low toxicity. The main drawback of such liposomes is that their cellular uptake shows a strong preference for endocytosis. A faster and more effective alternative for efficient molecular delivery is the induction of membrane fusion between liposomes and mammalian cells, whereby the cellular plasma membrane merges with the liposomal membrane and the cellular cytoplasm with the liposomal lumen. Therefore, liposomes are highly appropriate for simultaneous and multiple live cell functionalization. Moreover, molecular delivery by fusion completely bypasses endosomes, avoiding cargo degradation. For this reason, our main goal has been to develop lipid-based nanoparticles with high membrane fusion ability and to use those particles as universal carriers for biomolecules in pharmacological and biomedical applications.

Letzte Änderung: 12.10.2023