Steffen Docter

Steffen Docter

PhD Student

Forschungsthemen

Bioinformatics, Bioinformatik, Bioeconomy, Bioökonomie, MD Simulations, Enyzme Engineering, Machine Learning, Transaminasen, Transaminases

Kontakt

+49 2461/61-85653

E-Mail

Adresse

Forschungszentrum Jülich GmbH
Wilhelm-Johnen-Straße
52428 Jülich

Institut für Bio- und Geowissenschaften (IBG)

Bioinformatik (IBG-4)

Gebäude 05.11u / Raum 2011

Project: Knowledge- and data-driven engineering of transaminases

Transaminases are enzymes used in the pharmaceutical and fine chemical industry to produce chiral amines. We apply molecular dynamics simulations, protein rigidity analysis via Constraint Network Analysis (https://cpclab.uni-duesseldorf.de/index.php/Software) and machine learning algorithms for engineering of transaminases, focussing on improving thermostability, solvent tolerance, promiscuity and substrate specific activity. With this, we aim to find transaminases with improved performance in potential industrial applications.

Letzte Änderung: 07.01.2025