Selected Publications
Schulz CM, Agerschou ED, Gardon L, Alexander M, Stoldt M, Heise H, Tamgüney G, Hoyer W
Disordered regions of inhibitor-bound α synuclein suppress seed-induced fibril nucleation in cells.
Cell Rep Phys Sci (2024), 102180
Törner R, Kupreichyk T, Gremer L, Debled EC, Fenel D, Schemmert S, Gans P, Willbold D, Schoehn G, Hoyer W*, Boisbouvier J*
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin.
Nat Commun (2022), 13, 2363
Schützmann MP, Hasecke F, Bachmann S, Zielinski M, Hänsch S, Schröder GF, Zempel H, Hoyer W
Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting
Nat Commun (2021), 12, 4634
Hasecke F, Niyangoda C, Borjas G, Pan J, Matthews G, Muschol M, Hoyer W
Protofibril‐fibril interactions inhibit amyloid fibril assembly by obstructing secondary nucleation
Angew Chem Int Ed (2021), 60, 3016-3021
Agerschou ED, Borgmann V, Wördehoff MM, Hoyer W
Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein
Chem Sci (2020) 11, 11331-11337
Rösener NS, Gremer L, Wördehoff MM, Kupreichyk T, Etzkorn M, Neudecker P, Hoyer W
Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus
Commun Biol (2020), 3, 365
Röder C, Kupreichyk T, Gremer L, Schäfer LU, Pothula KR, Ravelli RBG, Willbold D, Hoyer W*, Schröder GF*
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils
Nat Struct Mol Biol (2020), 27, 660-667
Agerschou ED, Flagmeier P, Saridaki T, Galvagnion C, Komnig D, Heid L, Prasad V, Shaykhalishahi H, Willbold D, Dobson CM, Voigt A, Falkenburger B*, Hoyer W*, Buell AK*
An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils
Elife (2019), 8, e46112
Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CS, Matthews G, Meisl G, Knowles TP, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W*, Muschol M*
Origin of metastable oligomers and their effects on amyloid fibril self-assembly.
Chem Sci (2018), 9, 5937-5948
Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RB, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF
Fibril structure of amyloid-ß(1-42) by cryoelectron microscopy.
Science (2017), 358, 116-119
Shaykhalishahi H, Gauhar A, Wördehoff MM, Grüning CS, Klein A, Bannach O, Stoldt M, Willbold D, Härd T, Hoyer W
Contact between the β1 and β2 segments of α-synuclein inhibits amyloid formation.
Angew Chem Int Ed (2015), 54, 8837-8840
Mirecka EA, Shaykhalishahi H, Gauhar A, Akgül S, Lecher J, Willbold D, Stoldt M, Hoyer W
Sequestration of a β-hairpin for control of α-synuclein aggregation.
Angew Chem Int Ed (2014), 53, 4227-4230
