Prof. Dr. Gunnar Schröder
Head of Computational Structural Biology Group
Forschungszentrum Jülich GmbH
Institut für Biologische Informationsprozesse (IBI)
Gebäude 05.8v / Raum 3029
Warum und woran ich forsche
The group uses cryo-electron microscopy (cryo-EM) to determine the structure of amyloid proteins. We aim to understand the molecular basis of diseases that involve amyloid aggregation, such as Alzheimer's, Parkinsons's, and diabetes. For this, we study the polymorphism of amyloid fibrils of Aβ, α-synuclein, IAPP, and amyloid model systems such as SH3.
Furthermore, the group develops computational methods for modeling and refinement of protein structures using low resolution or sparse experimental data. The focus is on the integration of structure prediction approaches with experimental data from different sources such as single particle cryo-EM, X-ray crystallography and NMR.