PD Dr. Andreas Stadler

Senior Research Scientist at JCNS and Privatdozent at RWTH Aachen University

Forschungsthemen

neutron scattering, molecular biophysics, biophysical chemistry, X-ray scattering, biological matter, soft matter

Kontakt

+49 2461/61-4502

+49 2461/61-2610

E-Mail

https://www.fz-juelich.de/en/jcns/jcns-1/research/proteins

scholar.google

ORCID

Publons

Adresse

Forschungszentrum Jülich GmbH
Wilhelm-Johnen-Straße
52428 Jülich

Jülich Centre for Neutron Science (JCNS)

Neutronenstreuung und weiche Materie (JCNS-1)

Gebäude 04.8 / Raum 381

Research Focus

Research focus

My research group works in the field on Biophysical Chemistry and Molecular Biophysics. Our projects focus on the structure and dynamics of intrinsically disordered proteins, as well as their interaction with biological membranes. We study structure and dynamics of light sensitive proteins as well as monoclonal antibodies in solution. The experimental methods primarily used are neutron, X-ray, and light scattering techniques. Complementary imaging is performed using confocal fluorescence and electron microscopy. We apply mathematical modeling and computer simulation techniques for data analysis.

Projects

Intrinsically disordered proteins and biomimetic membranes

Structural dynamics of photosensitive proteins

LINXS monoclonal antibody in solution research project

Antibodies in solution: A LINXS - NIST Webinar Series

Vita

Committees and Boards

2023 Visiting guest researcher at LINXS in May & June, Lund University

2021 – 2025 Member of steering committee of “LINXS Antibodies in solution”

2021 – 2025 WP leader: “Single molecule dynamics of antibodies”

since 2019 LINXS Fellow, Lund University, Sweden

since 2025 Chair of Subcommittee 8 'Biology' of ILL, France

since 2025 Chair of Subcommittee “Soft Condensed Matter” of PSI, Switzerland

since 2023 Member of Subcommittee 8 'Biology' of ILL, France

since 2022 Member of Scientific Advisory Committee (SAC) of SINQ, PSI, Switzerland

since 2022 Member of Facility Access Panel Molecular Spectroscopy (FAP5) ISIS, UK

Employment

since 2015 Senior Research Scientist at JCNS-1 (permanent position)

2011-2015 Scientist at JCNS-1 & ICS-1 (tenure track position)

2009-2011 Postdoc at ICS-5

2006-2009 PhD at ILL, Grenoble, France

Academic degrees

2019 Habilitation and venia legendi in Chemistry, RWTH Aachen University, Germany

(Mentor: Prof. Dr. Walter Richtering)

2009 PhD, Physics for Life Science, Université Joseph Fourier, Grenoble, France

(Mentor: Dr. Giuseppe Zaccai)

2005 Diplom-Physiker, TU München, Germany

(Mentor: Prof. Dr. Fritz Parak)

2003 Master in Molecular Biophysics, Université Paris 6, France

(Mentor: Prof. Dr. Catherine Etchebest)

Publikationen

Full publication list: scholar.google.com

Selected publications: (*) Corresponding author A. M. Stadler

1. Peulen et al. Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase, eLife 12:e79565 (2023)

2. A. N. Hassani, L. Haris, M. Appel, T. Seydel, A. M. Stadler (*), G. R. Kneller

Multiscale relaxation dynamics and diffusion of myelin basic protein in solution studied by quasielastic neutron scattering

J. Chem. Phys. 156, 025102 (2022) https://doi.org/10.1063/5.0077100

3. B. Krugmann, A. Radulescu, M.‑S. Appavou, A. Koutsioubas, L. R. Stingaciu, M. Dulle, S. Förster, A. M. Stadler (*),

Membrane stiffness and myelin basic protein binding strength as molecular origin of multiple sclerosis.

Scientific Reports(2020) 10: 16691

DOI: 10.1038/s41598-020-73671-3

4. F. Ameseder, A. Radulescu, O. Holderer, P. Falus, D. Richter, and A. M. Stadler (*),

Relevance of Internal Friction and Structural Constraints for the Dynamics of Denatured Bovine Serum Albumin.

J. Phys. Chem. Lett. (2018) 9: 2469−2473

DOI: 10.1021/acs.jpclett.8b00825

5. (*) A. M. Stadler, F. Demmel, J. Ollivier and T. Seydel,

Picosecond to nanosecond dynamics provide a source of conformational entropy for protein folding.

Phys. Chem. Chem. Phys. (2016) 18: 21527-21538

DOI: 10.1039/C6CP04146A

6. (*) A.M. Stadler, L. Stingaciu, A. Radulescu, O. Holderer, M. Monkenbusch, R. Biehl, and D. Richter,

Internal Nanosecond Dynamics in the Intrinsically Disordered Myelin Basic Protein.

J. Am. Chem. Soc. (2014) 136: 6987−6994

DOI: 10.1021/ja502343b

7. A. M. Stadler, J P. Embs, I. Digel, G. M. Artmann, T. Unruh, G. Büldt, and G. Zaccai,

Cytoplasmic Water and Hydration Layer Dynamics in Human Red Blood Cells.

J. Am. Chem. Soc. (2008) 130: 16852–16853

DOI: 10.1021/ja807691j

Letzte Änderung: 25.07.2025