We aim at understanding the retina to develop better retinal implants for the therapy of blindness
The “Cellular Neurophysiology” research group investigates the physiological and pathophysiological mechanisms of ClC-3 and ClC-4 and the CLCN3/4-associated neuropathologies caused by their mutant variants. The ultimate goal is to develop novel therapeutics strategies for patients with this rare disease
We combine all-atom molecular simulations, machine learning, and computational structure prediction, together with quantitative functional experiments (e.g., patch-clamp electrophysiology, time-resolved fluorescence spectroscopy), to understand information processing in the brain under both normal and pathologic conditions at atomic resolution.
Normal cell function relies on proteins working properly at the right place, at the right time and at the right amount. The “Calcium Channel Biology” research group aims at understanding the regulation and cellular impact of ionic and non-ionic functions of voltage-activated calcium channels along the intracellular life cycle of the channel protein; from their synthesis in the endoplasmic reticulum, along their transport to their site of function and during their lifespan at the plasma membrane to their removal.
