Dr. Angela Kranz

Project Manager

Kompetenzbereiche

Project Management, Omics- and data-analysis, bioinformatics, bioeconomy, plant research, microbiology, research data management

Kontakt

+49 2461/61-85833

E-Mail

ORCID

Adresse

Forschungszentrum Jülich GmbH
Wilhelm-Johnen-Straße
52428 Jülich

Institut für Bio- und Geowissenschaften (IBG)

Bioinformatik (IBG-4)

Gebäude 06.5 / Raum 2004b

Warum und woran ich forsche

The IBG-4 (Bioinformatics) division of the Institute of Bio- and Geosciences develops and applies methods and algorithms to achieve a fundamental understanding of high-dimensional data and processes in the bioeconomy/life sciences and to understand, predict and optimize the biological functions of molecules, genes and enzymes for breeding and for industrial and pharmaceutical applications, also on the basis of their structures. IBG-4 has a focus on omics/data-based bioinformatics on plant data storage, the evaluation of new genome analysis methods, and the integration, interpretation, and visualization of high-dimensional omics data from the field of bioeconomy and plant science. More information here.

I am a biologist by training. My primary responsibility at IBG-4 involves managing projects that focus on research data management, as well as the development and improvement of databases and infrastructures. For example, one main focus of the projects affiliated with "Databases and Data Science" is the development and maintenance of ontologies for metadata annotation in fundamental plant sciences. Other topics that are of importance to us include the development of tools for creating Data Management Plans and converters that streamline the submission of data to external repositories and databases.

Vita

Since 2020: Projectmanager, Institute of Bio- and Geosciences (IBG-4: Bioinformatics), “Databases and Data Science”, Forschungszentrum Jülich

2017-2020: Postdoc, Institute of Bio- and Geosciences (IBG-1: Biotechnology), “Metabolic Regulation and Engineering” (Prof. Dr. Michael Bott), Forschungszentrum Jülich

2014-2017: PhD Thesis, Institute of Bio- and Geosciences (IBG-1: Biotechnology), “Genomics and Expression”, Forschungszentrum Jülich and Heinrich Heine University Düsseldorf

2007-2013: Diploma in Biology, Johannes Gutenberg University Mainz

Publikationen

García Brizuela J, Scharfenberg C, Scheuner C, Hoedt F, König P, Kranz A, Leidel A, Martini D, Schneider G, Schneider J, Singson L, von Waldow H, Wehrmeyer N, Usadel B, Lesch S, Specka X, Lange M, and Arend D (2024). A roadmap for a middleware as a federation service for integrative data retrieval of agricultural data. Journal of Integrative Bioinformatics. 21(3): 20240027.

Dumschott K, Dörpholz H, Laporte M-A, Brilhaus D, Schrader A, Usadel B, Neumann S, Arnaud E and Kranz A (2023): Ontologies for increasing the FAIRness of plant research data. Front. Plant Sci. 14:1279694.

Weil HL, Schneider K, Tschöpe M, Bauer J, Maus O, Frey K, Brilhaus D, Martins Rodrigues C, Doniparthi G, Wetzels F, Lukasczyk J, Kranz A, Grüning B, Zimmer D, Deßloch S, von Suchodoletz D, Usadel B, Garth C and Mühlhaus T (2023): PLANTdataHUB: a collaborative platform for continuous FAIR data sharing in plant research. Plant J 116: 974-988.

Zhou X-R, Beier S, Brilhaus D, Martins Rodrigues C, Mühlhaus T, von Suchodoletz D, Twyman RM, Usadel B and Kranz A (2023): DataPLAN: A Web-Based Data Management Plan Generator for the Plant Sciences. Data 8(11):159.

Kranz A, Polen T, Kotulla C et al. (2022): A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum. Scientific Data 9(1):594.

Schweikert S*, Kranz A*, Yakushi T, Filipchyk A, Polen T, Etterich H, Bringer S, and Bott M (2021): FNR-Type Regulator GoxR of the obligatorily aerobic acetic acid bacterium Gluconobacter oxydans affects expression of genes involved in respiration and redox metabolism. Applied and Environmental Microbiology 87(11): e00195-21.

Zhu L, Mack C, Wirtz A, Kranz A, Polen T, Baumgart M, and Bott M (2020): Regulation of γ-Aminobutyrate (GABA) utilization in Corynebacterium glutamicum by the PucR-Type transcriptional regulator GabR and by alternative nitrogen and carbon sources. Frontiers in Microbiology 11:544045.

Battling S*, Wohlers K*, Igwe C, Kranz A, Pesch M, Wirtz A, Baumgart M, Büchs J, and Bott M (2020): Novel plasmid-free Gluconobacter oxydans strains for production of natural sweetener 5-ketofructose. Microbial Cell Factories 19(1):54.

Kranz A, Steinmann A, Degner U, Mengus-Kaya A, Matamouros S, Bott M, and Polen T (2018): Global mRNA decay and 23S rRNA fragmentation in Gluconobacter oxydans 621H. BMC Genomics 19(1):753.

Kranz A, Busche T, Vogel A, Usadel B, Kalinowski J, Bott M, and Polen T (2018): RNAseq analysis of α-proteobacterium Gluconobacter oxydans 621H. BMC Genomics 19(1):24.

Kranz A*, Vogel A*, Degner U, Kiefler I, Bott M, Usadel B, and Polen T (2017): High precision genome sequencing of engineered Gluconobacter oxydans 621H by combining long nanopore and short accurate Illumina reads. Journal of Biotechnology 258:197-205.

Hochheim J, Kranz A, Krumbach K, Sokolowky S, Eggeling L, Noack S, Bocola M, Bott M, and Marienhagen J (2017): Mutations in MurE, the essential UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase of Corynebacterium glutamicum: Effect on L-lysine formation and analysis of systemic consequences. Biotechnology Letters 39(2): 283-288.

Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, Lewin HA, Ma J, Band M, Bicker A, Kranz A et al. (2014): Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nature Communications 5:3966.

*Both authors contributed equally to this work.

Letzte Änderung: 16.12.2024