Structural Biology (ER-C-3)

At the ER-C-3, we study the structural biology of essential cellular processes using electron cryo-microscopy (cryo-EM) as our central experimental tool. This technique allows biochemically purified macromolecular structures and multi-protein complexes being investigated in their near-native environment in vitro or inside cells without the need for crystallization.

Head: Prof. Carsten Sachse

In Focus



Autophagy is the cell’s housekeeping mechanism to engulf and degrade long-lived proteins, macromolecular aggregates, damaged organelles and even microbes in double-membrane vesicles called autophagosomes.

Electron cryomicroscopy

Electron cryomicroscopy

Electron cryomicroscopy is a powerful structural biology technique



Method development: Spring, Helical diffraction simulator and LocScale


Ernst Ruska-Centre The Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons is a combined development and user facility.

For electron microscopes

ER-C User Facility

The Ernst Ruska-Centre operates a wide range of state-of-the-art transmission electron microscopes, which are made available to external researchers from academia and industry.



Three outstanding institutes at Forschungszentrum Jülich are now joining forces to investigate this in more depth on an atomic level.