Institute for Advanced Simulation (IAS-6), Computational and Systems Neuroscience

Welcome to the Institute for Advanced Simulation (IAS-6), Computational and Systems Neuroscience

The brain is a highly complex organ and ubiquitous in our daily lives. However, little is understood about it or its functions. Undertaking the study of this organ is a challenging and fascinating endeavour and can spawn new technologies and alternative methods of treatment of diseases. Research at the Institute of Computational and Systems Neuroscience encompasses theoretical, data-analytic and simulation approaches to develop multi-scale models of the brain. It is our firm belief that progress in understanding a complex system like the brain can only be achieved through this multi-faceted approach.

Directors: Prof. Dr. Sonja Grün and Prof. Dr. Markus Diesmann

Institute for Advanced Simulation (IAS-6), Computational and Systems Neuroscience

Computational Neurophysics

The focus of the group led by Markus Diesmann is on bottom-up approaches in order to integrate physiological and anatomical data into models, in particular model development, theory of neuronal networks, and correlation dynamics. This also requires the development of simulation technology for neural networks.

Lead: Markus Diesmann, Director of IAS-6/ INM-10

Statistical Neuroscience

The research group of Sonja Grün focuses on the development of analysis strategies and tools that uncover concerted activity in electrophysiological signals from the brain.

Lead: Sonja Grün, Director of IAS-6/ INM-10

Computation in Neural Circuits

Investigation of mechanisms underlying neural computation through the development of models on the level of networks of spiking neurons. The group of Abigail Morrison applies a predominantly top-down approach to discover functional constraints on structure, plasticity and dynamics, particularly with respect to learning and memory.

Lead: Abigail Morrison

Theory of Multi-Scale Neuronal Networks

Moritz Helias' group focuses on mechanisms that shape the dynamics and information processing in biological and artificial neuronal networks. On the side of biological networks, we are interested in the relationship between the structure and dynamics of neural networks to unveil experimentally testable mechanisms of collective phenomena. For artificial neuronal networks, we develop the physics of AI that allows us to understand and quantify generalization properties and learning. Employing and developing statistical physics methods to formulate biological and artificial networks in a unified language allows us to discover overarching principles of information processing and to detect and quantify qualitative differences.

Lead: Moritz Helias

Theoretical Neuroanatomy

The work group led by Sacha van Albada studies the architecture and connectivity of brain circuits as the basis for neural network models at the resolution of neurons and synapses that relate structure to dynamics.

Lead: Sacha van Albada

Team Data Science of Electro- and Optophysiology in Behavioural Neuroscience

The team of Michael Denker addresses the practical challenges that arise in the context of data management and reproducible data analytics in neuroscience by applying concepts from physics and computer science.

Lead: Michael Denker

Team Future Simulation Architectures

Embracing the evolving landscape of high-performance computing systems, the team of Johanna Senk identifies challenges and explores solutions for neural network simulation technology.

Lead: Johanna Senk

News and Events

CSN Virtual Seminars

We host a series of Virtual Seminars at IAS-6. Past and upcoming events can be found here. The CSN Virtual Seminar Series (VSS) is a seminar series where guests mostly outside IAS-6 are invited to give talks that are entirely virtual, instead of on-site talks at the institute. The aim is to take advantage of the virtual format to have speakers from all over the world presenting their interesting science. The specific topic is chosen by the speaker.

New model brings astrocytes into large-scale brain simulations

A new study that started in the Human Brain Project (HBP) - and was enabled by EBRAINS - introduces a framework for including astrocytes into large-scale simulations of brain networks. In this study the researchers proposed a new, flexible, and scalable connectivity concept to represent how neurons and astrocytes interact in networks.

Latest Publications

State-dependent brain responsiveness, from local circuits to the whole brain

Destexhe A., Goldman J.S., Tort-Colet N., Roques A., Fousek J., Petkoski S., Jirsa V., David O., Jedynak M., Capone C., De Luca C.M.G., De Bonis G., Paolucci P.S., Mikulan E., Pigorini A., Massimini M., Galluzzi A., Pazienti A., Mattia M., Arena A., Juel B.E., Hagen E., Storm J.F., Montagni E., Resta F., Pavone F.S., Allegra M.A.L., Dwarakanath A., Panagiotaropoulos T.I., Senk J., Diesmann M., Camassa A., Dalla Porta L., Manasanch A., Sanchez-Vives M.V. (2025)

eLife 14:RP108768

DOI: 10.7554/eLife.108768.1

Field theory for optimal signal propagation in residual networks

Building on Models - A Perspective for computational Neuroscience

Data variability in neural network Bayesian inference

How Heterogeneity Shapes Dynamics and Computation in the Brain

Energy Constraints Determine the Selection of Reaching Movement Trajectories in Macaque Monkeys

Modeling Neuron-astrocyte interactions in neural networks using distributed simulation

Focal Sampling: SGD biased towards early important samples for efficient image classification with augmentation selection

A simplified model of NMDA-receptor-mediated dynamics in leaky integrate-and-fire neurons

Metadata practices for simulation workflows