Molecular engineering of novel crystalline phases using DNA

About

DNA is used as a programmable nanoscale bulding block for fabricating all-DNA and DNA-based particles with engineered shape and interaction potentials that could serve as model systems for exploring unconventional bulk phase behavior of diverse states of matter such as liquid crystals, crystalline phases and gels. To achieve our goals, we work in parallel with theory and simulation groups. Currently, the construction of a model cytoskeleton structure in artificial cells is underway. To accomplish this aim, microfluids is employed for the fabrication of DNA-based Liquid Crystal Elastomer (LCE) micro-shells.

Research Topics

DNA-based materials
Self-assembly
Liquid crystals
Patchy particles
Microscopy
Light scattering
Rheology
Small-angle X-ray scattering (SAXS)

Contact

Dr. Emmanuel Stiakakis

IBI-4

Building 04.6 / Room 74

+49 2461/61-3567

E-Mail

Members

Projects & Cooperations

EU-Project QLUSTER Project-Title: Quantum and Classical Ultrasoft Matter, 2023-2026

Gemeinsame Antragstellung mit Österreich und Schweiz (D-A-CH): DFG STI 664/4-1, Project title: Self-assembly of DNA Dendrimers in the Bulk and at Interfaces, 2016-2019.

Publications

Nataša Adžić, Clemens Jochum, Christos N. Likos, and Emmanuel Stiakakis: Engineering Ultrasoft Interactions in Stiff All-DNA Dendrimers by Site-Specific Control of Scaffold Flexibility, Small, 2308763 (2023) [DOI: 10.1002/smll.202308763]

I. Romero-Sanchez, I. Pihlajamaa, N. Adzic, L. E. Castellano, E. Stiakakis, C. N. Likos and M. Laurati: Blunt-end driven re-entrant ordering in quasi two-dimensional dispersions of spherical DNA brushes, ACS Nano, 16, 2133-2146 (2022). [DOI:10.1021/acsnano.1c07799 ]

K. Gvozden, S. Novak Ratajczak, Alberto G. Orellana, E. Kentzinger, U. Rücker, J. K. G. Dhont, C. De Michele and E. Stiakakis: Self-assembly of all-DNA rods with controlled patchiness, Small,18, 2104510 (2022). [DOI:10.1002/smll.202104510]

E. Stiakakis, N. Jung, N. Adzic, T. Balandin, E. Kentzinger, U. Rücker, R.Biehl, J. K. G. Dhont, U. Jonas and C. N. Likos: Self assembling cluster crystals from DNA based dendritic nanostructures, Nat. Commun., 12, 7167 (2021). [DOI:10.1038/s41467-021-27412-3]

S. Novak, J. Zhang, E. Kentzinger, U. Rücker, G. Portale, N. Jung, U. Jonas, J. S. Myung, R. G. Winkler, G. Gompper, J. K. G. Dhont and E. Stiakakis: DNA Self-Assembly Mediated by Programmable Soft-Patchy Interactions, ACS Nano, 14, 13524-13535 (2020). [https://doi.org/10.1021/acsnano.0c0553]

C. Jochum, N. Adzic, E. Stiakakis, T. L. Derrien, D. Luo, G. Kahl and C. N. Likos: Structure and stimuli-responsiveness of all-DNA dendrimers: theory and experiment, Nanoscale, 11, 1604 (2019). [https://doi.org/10.1039/C8NR05814H]

M. Salamonczyk, J. Zhang, G. Portale, C. Zhu, E. Kentzinger, J. T. Gleeson, A. Jakli, C. De Michele, J. K. G. Dhont, S. Sprunt and E. Stiakakis: Smectic phase in suspensions of gapped DNA duplexes, Nat. Commun. 7, 13358 (2016). [DOI: 10.1038/ncomms13358]

Last Modified: 14.11.2024

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Institute of Biological Information Processing (IBI)

Biomacromolecular Systems and Processes (IBI-4)

Molecular engineering of novel crystalline phases using DNA

About

Research Topics

Contact

Members