Protein Aggregation and Phase Behaviour in Electric Fields
About
My research fields are focused on collective phase behaviours of charged DNA-viruses (fd) in both non-equilibrium (electric-field and shear-flow) and equilibrium, together with developments of novel scientific instrumentation, light scatterings and image-time correlation spectroscopy.
Emergent experimental results have been provided semi-empirical theories on charged species, in particular, low-frequency driven dynamical states of charged DNA rods, field-inducedmicroscopic dynamics and critical slowing down behaviors (glass phenomena) as well the flow response of soft rod-glasses with 3d bulk pattern formations. In the equilibrium phase diagram of charged DNA-rods at low ionic strengths, the orientation kinetics of charged DNA-rods are explored by image-time correlations, which also applied to other interested materials (T4 DNA, lysozyme with antagonistic salt, cellulose nano-fibers/crystals, etc).
As ongoing research interests, the protein phase behaviours and amorphous protein aggregations in weak electric fields are to revealed by roles of dissociation constant for condensed ions in both non-equilibrium and equilibrium. To what extent can protein aggregation be inhibited/enhanced by electric fields (also in mixtures of different proteins)? The main topic is how the electric field-induced change of the electrical double layer affect on the structure of proteins (exposure of hydrophobic groups).
Research Topics
- The effect of electric fields, shear flow, and confinement on the dynamics and self-assembly as well as field-induced instabilities of suspensions of anisotropic nano-particles.
- Protein aggregation and phase behaviour in electric fields.

Members
DFG Einzelantrag “Protein phase behaviour in electric fields“, with the HHU (Dr. Florian Platten).
The effect of fatty acids, ionic strength, and electric fields on the microscopic dynamics of BSA aggregates
Equilibrium phase diagram and thermal responses of charged DNA‑virus rod‑suspensions at low ionic strengths
Characterization of orientation correlation kinetics: chiral-mesophase domains in suspensions charged DNA-rods