New Study Reveals Improved Dead Time Correction in PET Brain Imaging

5th April 2024

A recent study conducted by INM-4 researchers has identified a more accurate block-pairwise DTC method to improve the accuracy of PET brain imaging. Examining various radioactive tracers, including [¹¹C]ABP688, O-(2-[¹⁸F]fluoroethyl)-L-tyrosine (FET), and [¹⁵O]H₂O, the study demonstrated significant differences between the currently used global DTC method and the novel block-pairwise DTC method.

Results emphasised the block-pairwise method's superiority in minimising biases in output parameters such as volume of distribution (VT) and tumour-to-brain ratio (TBRmax).

The study's implications are pertinent for neuroscientific research, offering improved accuracy in quantitative measurements critical for understanding brain function and pathology.

Origional publication: Impact of improved dead time correction on the quantification accuracy of a dedicated BrainPET scanner