The Team “INW Long-Term Characterization X-Ray Laboratory” designs, develops, builds, and operates a worldwide unique laboratory high-energy X-ray beamline for stroboscopic cross-scale structural operando long-term investigations of the function and degradation of chemical and electrochemical energy storage materials. The focus is on the investigation of thermocatalytic (combinatorially run) reactors for chemical hydrogen storage, whereby the high X-ray energies enable the use of realistic reactors. The methods include (high-resolution) diffraction, pair distribution function, surface scattering, small-angle scattering, and wide-angle scattering. Operated in high-throughput with the corresponding reactor systems, this beamline enables combinatorial data sets, which are evaluated using big data analytics and machine learning. In addition, the beamline enables the measurement of “data on demand” to accelerate technology development.