Diffusion MRI has established itself as an invaluable tool for the non-invasive probing of tissue microstructure and dynamics. As such, it has given rise to unique opportunities in brain diagnostics such as stroke and has demonstrated a remarkable success in assessing white matter fibre orientations. Conventional methods, however, suffer from intrinsic limitations based on a simplified assumption of Gaussian diffusion. Serious limitations are also related to the low angular resolution of the standard fibre tracking methods.
To address these limitations, we design advanced methods which allow us to essentially increase both the angular resolution (HARDI) and the range of the diffusion-encoding gradient strengths (non-Gaussian diffusion). In turn, this provides us with enhanced information about diffusion mechanisms, the underlying microstructure and brain function. In cooperation with internal and external partners, we examine the potential applications of the new tools with respect to brain monitoring and diagnostics.