Discovery of [18F]JK-PSMA-7 as a novel PET probe for the detection of small PSMA-positive lesions

Abstract

Prostate-specific membrane antigen (PSMA) represents a promising target for PET imaging of prostate cancer, as it is almost exclusively expressed in malignant prostate tumors. To improve PSMA-targeted PET imaging, a series of PSMA-binding radioligands were developed and preclinically evaluated. Among these, the compound [¹⁸F]JK-PSMA-7 was identified as a particularly promising candidate for the high-contrast visualization of small PSMA-positive lesions. The high diagnostic value of this radiotracer has also been confirmed by independent results summarized in more than 20 publications from various clinics worldwide, leading to its advancement into Phase 3 clinical trials.

Zlatopolskiy, B.; Endepols, H.; Krapf, P.; Guliyev, M.; Urusova, E. A.; Richarz, R.; Hohberg, M.; Dietlein, M.; Drzezga, A.; Neumaier, B.

Discovery of 18F-JK-PSMA-7, a PET Probe for the Detection of Small PSMA-Positive Lesions

Journal of nuclear medicine 2019, 60 (6), 817-823.