Cytoarchitecture linked to gene expression to study multilevel human brain organization
Decoding the chain from genes to cognition requires detailed insights how areas with specific gene activities and microanatomical architectures contribute to brain function and dysfunction. The Allen Human Brain Atlas contains regional gene expression data, while Julich-Brain Atlas offers three-dimensional cytoarchitectonic maps reflecting interindividual variability. To date, an integrated framework that combines the analytical benefits of both scientific platforms towards a multi-level brain atlas of adult humans was not available. We have therefore developed JuGEx, a new method for integrating tissue transcriptome and cytoarchitectonic segregation.
The JuGEx workflow and the GUIs are based on a script distribution that was coded in Matlab (version R2015b, 64bit).
This research was supported by the European Union Seventh Framework program (FP7/2007-2013) Grant 604102 (Human Brain Project) to K.A. and S.C.
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