Referent:

Dr. Jens Elgeti, ICS-2

Inhalt:

Cells grow and divide, which implies a change in volume. In physical terms, the conjugate force to a change in volume is a pressure. Thus, in order to grow, cells must exert mechanical pressure on the neighbouring tissue. In turn, mechanical stress influences growth. Indeed, experiments on the growth of a cancer cell line display a reduction in proliferation due to mechanical pressure [1,2,3]. This effect leads to a mechanical contribution when tissues compete for space. The tissue with higher homeostatic pressure, i.e. the pressure at which cell division and death balance, overwhelms the weaker one [4,5]. We use particle based computer simulations [4] to model growing tissues. In this talk, I will review the simulation method, and highlight the algorithmical challenges involved. I will show how simulations contributed to key findings in the field, and finally present results of the ongoing accounting period regarding competition of different tissues.

[1] Montel et al, 2011, PRL 107, 188102
[2] Delanrue et al, 2013, PRL110, 138103
[3] Podewitz et al, 2016, EPL 109, 58005
[4] Basan et al, 2011, Phys. Biol. 8, 026014
[5] Podewitz et al, 2016 New J. Physics 18, 083020

Zeit:

Mittwoch, 25. April 2018, 14:00 - 14:30

Ort:

Jülich Supercomputing Centre, Hörsaal, Geb. 16.3, R. 222

2. Vortrag:

Atmospheric Chemistry in the Earth System - Process understanding aided by supercomputing in the jicg23 project

Referent:

Dr. Domenico Taraborrelli, IEK-8

Inhalt:

Deciphering the underlying mechanisms determining atmospheric composition is a quest which requires lab, field and modelling investigations. The latter are essential for understanding air quality and chemistry-climate interactions. However, computations of detailed chemical processes, especially kinetics, demand an order of magnitude more resources than normal climate models do. Therefore, supercomputing is indispensable to advance our knowledge of chemistry-mediated feedbacks in the Earth System. In this talk the models used within the JURECA project jicg23 will be introduced. Then, an overview of the undertaken scientific research will be given. Afterwards, the ongoing optimization of critical algorithms for the architectures at hand will be presented. Finally, preparatory work for developing the future HGF Earth System Model (HGF-ESM) and for performing „frontier simulations“ on JUWELS will be outlined.

Zeit:

Mittwoch, 25. April 2018, 14:30 - 15:00

Ort:

Jülich Supercomputing Centre, Hörsaal, Geb. 16.3, R. 222