PyMVPA is a Python package intended to ease statistical learning analyses of large datasets. It offers an extensible framework with a high-level interface to a broad range of algorithms for classification, regression, feature selection, data import and export. It is designed to integrate well with related software packages, such as scikit-learn, shogun, MDP, etc. While it is not limited to the neuroimaging domain, it is eminently suited for such datasets. PyMVPA is free software and requires nothing but free-software to run.