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Figure 1 - (A) Crystal structure of activated beta-2 adrenergic receptor in complex with heterotrimeric G-protein Gs (PDB entry 3SN6). The receptor is colored red, G? green, G? cyan and G? yellow. (B) Schematic representation of GPCR/G-protein interactions during signaling in eukaryotes. State 1: G-protein inactive state. State 2: GDP/GTP exchange, first step of activation. State 3: dissociation of G?•GTP from the tightly bound G?•G? dimer.