We work on the development and study of properties of electrochemical multisensor systems with redox proteins, oxidoreductase enzymes, molecular macrocycles, and their nanostructures based on molecular assembly for simultaneous detection and monitoring of reactive oxygen species, ions, ion/molecular transport, and redox signaling in single cells, cellular systems, and tissues.
The research emphases are:
- Metalloporphyrins and related macrocycles and their supramolecular assemblies for electrochemical sensors and catalysis.
- Mechanisms of the electron transfer to the electrode surface (e.g., dynamics of the analyte coordination; structure of the intermediates; electron transfer constants).
- Miniaturization of the electrochemical sensors. The remarkable sensitivity of new nanomaterial-based sensors opens up the possibility of detecting small quantities of analytes with high temporal and spatial resolution and investigating biological pathways that cannot be measured by conventional methods. Charge transfer between electrocatalytic centre of enzymes and transducer, which can be facilitated by electrochemical mediators and nanoelectronic building blocks is of particular interest.
- Analytical sensors characterization and analysis in model solutions, cells, and cellular systems.
We utilizes electrochemical techniques as well as a variety of spectroscopic, analytical, and structural analysis techniques to accomplish these goals.
Synthesizing Electrodes Into Electrochemical Sensor Systems. Yu. G. Mourzina et al., Frontiers Chemistry, Volume 9, Issue129, 2021.
Biomimetic sensor based on Mn(III) meso-tetra(N-methyl-4-pyridyl) porphyrin for non-enzymatic electrocatalytic determination of hydrogen peroxide and as an electrochemical transducer in oxidase biosensor for analysis of biological media. R. Peng et al., Sensors and Actuators B, Volume 321, 128437, 2020.
Electrochemical properties and biomimetic activity of water-soluble meso-substituted Mn(III) porphyrin complexes in the electrocatalytic reduction of hydrogen peroxide. Yu. G. Mourzina et al., Journal of Electroanalytical Chemistry, Volume 866, 114159, 2020.
Photoresponsive Porphyrin Nanotubes of Meso-tetra(4-Sulfonatophenyl)Porphyrin and Sn(IV) meso-tetra(4-pyridyl)porphyrin.E. A. Koposova et al., Frontiers in Chemistry, Volume 7, Article Number 351, 2019.
Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions.K. G. Nikolaev et al., Frontiers in Chemistry, Volume: 6, Article Number: 256, 2018.