Liang Ma

Sara Reithofer

Alumni:

Verena Pesch

Anja Schaffrath

Jessica Schneide

Katja Jansen

Chiara Kroepel

International collaborations

University of Alberta, Edmonton, Alberta, Canada (Prof. Dr. Holger Wille)

Vaccine development for Parkinson’s disease and other synucleinopathies

Calibr, Scripps Research, La Jolla, California, USA (Dr. Arnab Chatterjee)

Drug development for Parkinson’s disease and other synucleinopathies

National collaborations

Universität Rostock (Prof. Dr. Gabriele Doblhammer)

Investigation of infectious diseases as risk factors in Parkinson’s diseases and dementia

University Hospital Cologne (Prof. Dr. Michael Barbe, Prof. Dr. Özgür Onur, PD Dr. Michael Sommerauer)

Establishment of the Köln-Jülich-Biobank and development of diagnostics for Parkinson’s and Alzheimer’s disease

Lead Discovery Center GmbH, Dortmund (Dr. Bert Klebl, Dr. Jan Eickhoff)

Drug development for Parkinson’s disease and other synucleinopathies

Priavoid GmbH, Düsseldorf (Dr. Antje Willuweit)

Development of D-peptides as therapeutics for Parkinson’s disease

Internal Collaborations

Dr. Oliver Bannach

Development of sFIDA as a diagnostic laboratory test for Parkinson’s and Alzheimer’s disease

Prof. Dr. Gunnar Schröder

Cryo-EM based structure analysis of alpha-synuclein fibrils

Prof. Dr. Birgit Strodel

Supercomputer-aided drug development for the treatment of synucleinopathies

Prof. Dr. Dieter Willbold und Dr. Jeannine Mohrlüder

• Blömeke L, Pils M, Kraemer-Schulien V, Dybala A, Schaffrath A, Kulawik A, Rehn F, Cousin A, Nischwitz V, Willbold J, Zack R, Tropea TF, Bujnicki T, Tamgüney G, Weintraub D, Irwin D, Grossman M, Wolk DA, Trojanowski JQ, Bannach O, Chen-Plotkin A, Willbold D
  Quantitative detection of α-synuclein and tau oligomers and other aggregates by digital single particle counting
  NPJ Parkinsons Dis, 8, 68 (2022)

https://doi.org/10.1038/s41531-022-00330-x

• Lohmann S, Grigoletto J, Bernis ME, Pesch V, Ma L, Reithofer S, Tamgüney G
  Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein
  Acta Neuropathol Commun, 10, 26 (2022)
  
  https://rdcu.be/cHITe

• Woerman AL and Tamgüney G
  Body-first Parkinson’s disease and variant Creutzfeldt–Jakob disease – similar or different?
  Neurobiol Dis, 164, 105625 (2022)
  
  https://doi.org/10.1016/j.nbd.2022.105625

• Fink A, Doblhammer G, Tamgüney G
  Recurring gastrointestinal infections increase the risk of dementia
  J Alzheimers Dis 84, 797-806 (2021)
  
  https://doi.org/10.3233/JAD-210316

• Santur K, Reinartz E, Lien Y, Tusche M, Altendorf T, Sevenich M, Tamgüney G, Mohrlüder J, Willbold D
  Ligand-induced stabilization of the native human superoxide dismutase 1
  ACS Chem Neurosci 12, 2520-2528 (2021)
  
  https://doi.org/10.1021/acschemneuro.1c00253

• Van Den Berge N, Ferreira N, Mikkelsen TW, Alstrup AKO, Tamgüney G, Karlsson P, Terkelsen AJ, Nyengaard JR, Jensen PH, Borghammer P
  Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats
  Brain 144, 1853-1868 (2021)
  
  https://doi.org/10.1093/brain/awab061

• Bernis ME and Tamgüney G
  Bioluminescence imaging of neuroinflammation in a mouse model of Parkinson's disease
  Methods Mol Biol 2081, 147-159 (2020)
  
  https://doi.org/10.1007/978-1-4939-9940-8_10

• Van Den Berge N, Ferreira N, Gram H, Mikkelsen TW, Alstrup AKO, Casadei N, Tsung-Pin P, Riess O, Nyengaard JR, Tamgüney G, Jensen PH, Borghammer P
  Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats
  Acta Neuropathol 138, 535-550 (2019)
  
  https://doi.org/10.1007/s00401-019-02040-w

• Lohmann S, Bernis ME, Babila JT, Ziemski A, Grigoletto J, Tamgüney G
  Oral and intravenous transmission of α-synuclein fibrils to mice
  Acta Neuropathol 138, 515-533 (2019)
  
  https://doi.org/10.1007/s00401-019-02037-5

• Nerius M, Doblhammer G, Tamgüney G
  GI infections are associated with an increased risk of Parkinson’s disease
  Gut 66, 1-2 (2020)
  
  https://doi.org/10.1136/gutjnl-2019-318822

• Wüsten KA, Reddy PP, Smiyakin A, Bernis ME, Tamgüney G
  A bioluminescent cell assay to quantify prion protein dimerization
  Sci Rep 8, 14178 (2018)
  
  https://doi.org/10.1038/s41598-018-32581-1

• Tamgüney G and Korczyn AD
  A critical review of the prion hypothesis of human synucleinopathies
  Cell Tissue Res 373, 213-220 (2017)
  
  https://doi.org/10.1007/s00441-017-2712-y

• Breid S, Bernis ME, Babila JT, Garza MC, Wille H, Tamgüney G
  Bioluminescence imaging of neuroinflammation in transgenic mice after peripheral inoculation of alpha-synuclein fibrils
  J Vis Exp (122) e55503 (2017)
  
  https://doi.org/10.3791/55503

• Tachu BJ, Wüsten KA, Garza MC, Wille H, Tamgüney G
  An easy method for bacterial expression and purification of wild-type and mutant superoxide dismutase 1 (SOD1)
  Protein Expr Purif 134, 63-71 (2017)
  
  https://doi.org/10.1016/j.pep.2017.04.001

• Breid S, Bernis ME, Babila JT, Garca MC, Wille H, Tamgüney G
  Neuroinvasion of α-synuclein prionoids after intraperitoneal and intraglossal inoculation
  J Virol 90, 9182-9193 (2016)
  
  https://doi.org/10.1128/JVI.01399-16

• Bernis ME, Babila JT, Breid S, Wüsten KA, Wüllner U, Tamgüney G
  Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
  Acta Neuropathol Commun 3, 75 (2015)
  
  https://doi.org/10.1186/s40478-015-0254-7

• Tamgüney G, Giles K, Oehler A, Johnson NL, DeArmond SJ, Prusiner SB
  Chimeric elk/mouse prion proteins in transgenic mice
  J Gen Virol 94, 443-452 (2013)
  
  https://doi.org/10.1099/vir.0.045989-0

• Tamgüney G, Richt JA, Hamir AN, Greenlee JJ, Miller MW, Wolfe LL, Sirochman TM, Young AJ, Glidden DV, Johnson NL, Giles K, DeArmond SJ, Prusiner SB
  Salivary prions in sheep and deer
  Prion 6, 52-61(2012)
  
  https://doi.org/10.4161/pri.6.1.16984

• Tamgüney G, Miller WM, Wolfe LL, Sirochman TM, Glidden DV, Palmer C, Lemus A, DeArmond SJ, Prusiner SB
  Asymptomatic deer excrete infectious prions in feces
  Nature 461, 529-532 (2009)
  
  https://doi.org/10.1038/nature08289

• Tamgüney G, Francis KP, Giles K, Lemus A, DeArmond SJ, Prusiner SB
  Measuring prions by bioluminescence imaging
  Proc Natl Acad Sci U S A 106, 15002-15006 (2009)
  
  https://doi.org/10.1073/pnas.0907339106

• Tamgüney G, Miller WM, Giles K, Lemus A, Glidden DV, DeArmond SJ, Prusiner SB
  Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein
  J Gen Virol 90, 1035-1047 (2009)
  
  https://doi.org/10.1099/vir.0.007500-0

• Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Dawson Cruz T, Kuziel WA, Maeda N, Sap J, Hsiao Ashe K, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB
  Genes contributing to prion pathogenesis
  J Gen Virol 89, 1777-1788 (2008)
  
  https://doi.org/10.1099/vir.0.2008/001255-0

• Safar JG, Lessard P, Tamgüney G, Freyman Y, Deering C, Letessier F, DeArmond SJ, Prusiner SB
  Transmission and detection of prions in feces
  J Infect Dis 198, 81-89 (2008)
  
  https://doi.org/10.1086/588193

• Tamgüney G, Giles K, Bouzamondo-Bernstein E, Bosque PJ, Miller MW, Safar J, DeArmond SJ, Prusiner SB
  Transmission of elk and deer prions to transgenic mice
  J Virol 80, 9104-9114 (2006)
  
  https://doi.org/10.1128/JVI.00098-06

• Tamgüney G, van Snick J, Fickenscher H
  Autocrine stimulation of rhadinovirus-transformed T cells by the chemokine CCL1/I-309 Oncogene 23, 8475-8485 (2004)
  
  https://doi.org/10.1038/sj.onc.1207903

• Greve T*, Tamgüney G*, Fleischer B, Fickenscher H, Bröker BM
  Downregulation of p56^lck kinase activity in T cells of squirrel monkeys (Saimiri sciureus) correlates with the non-transforming and apathogenic properties of herpesvirus saimiri in its natural host
  J Virol 75, 9252-9261 (2001) (*equal contribution)
  
  https://doi.org/10.1210/jcem.86.11.7998

• Gröschl M, Rauh M, Wagner R, Neuhuber W, Metzler M, Tamgüney G, Zenk J, Schoof E, Dörr HG, Blum WF, Rascher W, Dötsch J
  Identification of leptin in human saliva
  J Clin Endocrinol Metab 86, 5234-5239 (2001)
  
  https://doi.org/10.1210/jcem.86.11.7998

• Hiller C, Tamgüney G, Stolte N, Mätz‑Rensing K, Lorenzen D, Hör S, Thurau M, Wittmann S, Slavin S, Fickenscher H
  Herpesvirus saimiri pathogenicity enhanced by thymidine kinase of herpes simplex virus
  Virology 278, 445‑455 (2000)
  
  https://doi.org/10.1006/viro.2000.0665