Structural Basis of Protein Signaling
We study structure-function relationships in proteins of biological and biotechnological importance, combining biochemical, biophysical, and X-ray crystallographic techniques.
- Protein crystallography
- Blue-light photoreceptor proteins
- arrestin-GPCR interaction
- Protein-ligand interactions
- Protein aggregation
Prof. Dr. Renu Batra-Safferling
Building 05.8v / Room 3019
The primary focus of our research group is to understand the structure-function relationships of soluble and membrane proteins of biological importance. Our approach remains to conduct these studies with techniques that allow a complete dissection of kinetic and structural properties of the proteins in static and dynamic states. The three-dimensional structure is determined by X-ray crystallographic techniques. The structural, functional and thermodynamic properties on wild-type and modified forms of the macromolecules generated by site-directed mutagenesis are studied extensively using transient and steady-state kinetics, as well as selected biophysical techniques.
PD Dr. Joachim Granzin