I. Blue-light photoreceptors / LOV proteins

Collaboration Partners:

- IMET HHU Düsseldorf / IBG-1, Forschungszentrum Jülich GmbH, Germany

(Professor Karl-Erich Jaeger, Dr. Ulrich Krauss, Dr. Thomas Drepper)

- JCNS-1, ICS-1, Forschungszentrum Jülich GmbH Germany, And Institute of Physical Chemistry, RWTH Aachen University, Aachen, Germany

(PD Dr. Andreas M Stadler)

II. Novel Hydrolases

Collaboration Partners:

- IMET / IBG-1, Forschungszentrum Jülich GmbH, Germany

(Professor Karl-Erich Jaeger, Dr. Filip Kovacic)

III. GPCR-Arrestin interaction

Collaboration Partners:

- JCNS-1, ICS-1, Forschungszentrum Jülich GmbH Germany, and Institute of Physical Chemistry, RWTH Aachen University, Aachen, Germany

(PD Dr. Andreas M Stadler)

- Freie Universität Berlin, Experimental Physics: Genetic Biophysics, Berlin, Germany

(Dr. Ramona Schlesinger)

- Bleffert F, Granzin J, Caliskan M, Schott-Verdugo SN, Siebers M, Thiele B, Rahme L, Felgner S, Dörmann P, Gohlke H* , Batra-Safferling R*, Jaeger K-E, Kovacic F*. Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa. eLife 11, e72824 (2022) https://doi.org/10.7554/eLife.72824

- Arinkin V, Granzin J, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R*. Structural determinants underlying the adduct lifetime in the LOV proteins of Pseudomonas putida. The FEBS Journal (2021). https://doi.org/10.1111/febs.15785

- Stadler AM, Granzin J, Cousin A, Batra-Safferling R*. Phosphorylated peptide of G protein-coupled receptor induces dimerization in activated arrestin. Scientific Reports 10, 10938 (2020) https://doi.org/10.1038/s41598-020-67944-0

- Arinkin V, Granzin J, Röllen K, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R*. Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools. Scientific Reports 7(42971), (2017) http://dx.doi.org/10.1038/srep42971

- Röllen K, Granzin J, Panwalkar V, Arinkin V, Rani R, Hartmann R, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R*. Signaling States of a Short Blue-Light Photoreceptor Protein PpSB1-LOV Revealed from Crystal Structures and Solution NMR Spectroscopy. J Mol Biol. 428, 3721 - 3736 (2016). http://dx.doi.org/10.1016/j.jmb.2016.05.027

- Endres S, Granzin J, Circolone F, Stadler A, Krauss U, Drepper T, Svensson V, Knieps-Grünhagen E, Wirtz A, Cousin A, Tielen P, Willbold D, Jaeger K-E*, Batra-Safferling R*. Structure and function of a short LOV protein from the marine phototrophic bacterium Dinoroseobacter shibae. BMC Microbiology 15, 30 (2015). http://www.biomedcentral.com/1471-2180/15/30

- Granzin J, Stadler A, Cousin A, Schlesinger R, Batra-Safferling R*. Structural evidence for the role of polar core residue Arg175 in arrestin activation. Scientific Reports 5, 15808 (2015). http://www.nature.com/articles/srep15808

- Circolone F, Granzin J, Jentzsch K, Drepper T, Jaeger K-E, Willbold D, Krauss U*, Batra-Safferling R*. Structural basis for the slow dark recovery of a full-length LOV protein from Pseudomonas putida. J. Mol. Biol. 417, 362–374 (2012). http://doi.org/10.1016/j.jmb.2012.01.056

- Granzin J, Cousin A, Weirauch M, Schlesinger R, Büldt G, Batra-Safferling R*. Crystal structure of p44, a constitutively active splice variant of visual arrestin. J Mol Biol. 416(5), 611-8 (2012). http://dx.doi.org/10.1016/j.jmb.2012.01.028

- Batra-Safferling R, Abaraca-Heidemann K, Körschen HG, Tziatzios C, Stoldt M, Budyak I, Willbold D, Schwalbe H, Klein-Seetharaman J, Kaupp UB. Glutamic acid-rich proteins of rod photoreceptors are natively unfolded. J Biol Chem 281, 1449-1460 (2006) http://DOI:10.1074/jbc.M505012200

- Batra R, Khayat R, Tong L. Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nature Struct Biol. 8(9), 810-7 (2001) http://doi:10.1038/nsb0901-810