How does aggressive behavior arise in patients with mental disorders? What role do cognitive, environmental, and biological factors, as well as disease symptoms, play in understanding and the occurrence of aggressive behavior? How can we treat aggressive behavior in patients with mental disorders better? A team of researchers from various universities is addressing these questions through a longitudinal, developmental, multidimensional, transdiagnostic approach in the TRR 379. They aim at identifying transdiagnostic biosignatures to enable a more specific prevention and treatment.