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Institute of Neuroscience and Medicine
Nuclear Chemistry (INM-5)
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[18F]FAAA

Preparation of labeled aromatic amino acids via late-stage 18F-fluorination of chiral nickel and copper complexes

A general protocol for the preparation of 18F-labeled aromatic amino acids (AAA) and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of pinacol arylboronate (Bpin)-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. More: Preparation of labeled aromatic amino acids via late-stage 18F-fluorination of chiral nickel and copper complexes …

Logo Dual2Pet

Using PET for the Evaluation of Innovative Analgetics with Dual Mode of Action (Dual²PET)

Innovative drugs targeting two modes of action based on one chemical structure are a promising novel therapeutic approach in medicine. More: Using PET for the Evaluation of Innovative Analgetics with Dual Mode of Action (Dual²PET) …

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PAIN-Vis

Novel PET tracers provide promising opportunities to study molecular pathological changes associated with peripheral pain and enables to determine its exact location in the body. More: PAIN-Vis …


Focus

Büro / Office

Radiotracer development

The first prerequisite of radiotracer development is an identification of the molecular target. Molecular targets can be specifically addressed by using corresponding lead structures. Usually these lead structures belong to for example enzyme substrates or receptor ligands. More: Radiotracer development …

Spritze mit Vials / Syringe with Vials

Radiopharmaceutical production

The INM-5 produces radiopharmaceuticals for the Positron Emission Tomography (PET) and supplies both FZJ internal institutions and external University clinics (Universities of Aachen, Bonn, Cologne, Münster, among others). More: Radiopharmaceutical production …

Fluorethyltyrosin

PET-Imaging

PET imaging enables to non-invasively visualize the structure, function, wiring and chemistry of the human brain. More: PET-Imaging …

Zyklotron

Cyclotron

Usually, all radionuclides applied in molecular imaging have to be produced at an accelerator. More: Cyclotron …

Nuklidkarte / Nuclide chart

Non-standard radionuclides

With the growing impact of PET in clinical diagnosis, besides standard positron emitters the need for novel, non-standard positron emitters, e.g. 64Cu, 73Se, 76Br or 120I, is evident. More: Non-standard radionuclides …

Information

Information

Learn more about PET and MRI More: Information …


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