Articles 2021

Pagnon de la Vega M, Giedraitis V, Michno W, Kilander L, Güner G, Zielinski M, Löwenmark M, Brundin R, Danfors T, Söderberg L, Alafuzoff I, Nilsson LNG, Erlandsson A, Willbold D, Müller SA, Schröder GF, Hanrieder J, Lichtenthaler SF, Lannfelt L, Sehlin D, Ingelsson M.
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.
Sci Transl Med. 2021 Aug 11;13(606):eabc6184. doi: 10.1126/scitranslmed.abc6184. Erratum in: Sci Transl Med. 2022 Jan 12;14(627):eabn9847. doi: 10.1126/scitranslmed.abn9847. PMID: 34380771.

Schützmann MP, Hasecke F, Bachmann S, Zielinski M, Hänsch S, Schröder GF, Zempel H, Hoyer W.
Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting.
Nat Commun. 2021 Jul 30;12(1):4634. doi: 10.1038/s41467-021-24900-4. PMID: 34330900; PMCID: PMC8324842.

Zielinski M, Röder C, Schröder GF.
Challenges in sample preparation and structure determination of amyloids by cryo-EM.
J Biol Chem. 2021 Aug;297(2):100938. doi: 10.1016/j.jbc.2021.100938.
Epub 2021 Jul 3. PMID: 34224730; PMCID: PMC8335658.

Willbold D, Strodel B, Schröder GF, Hoyer W, Heise H.
Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids.
Chem Rev. 2021 Jul 14;121(13):8285-8307. doi: 10.1021/acs.chemrev.1c00196. Epub 2021 Jun 17. PMID: 34137605.

Pothula KR, Geraets JA, Ferber II, Schröder GF.
Clustering polymorphs of tau and IAPP fibrils with the CHEP algorithm.
Prog Biophys Mol Biol. 2021 Mar;160:16-25. doi: 10.1016/j.pbiomolbio.2020.11.007. Epub 2021 Feb 6. PMID: 33556421.

Lawson CL, Kryshtafovych A, Adams PD, Afonine PV, Baker ML, Barad BA, Bond P, Burnley T, Cao R, Cheng J, Chojnowski G, Cowtan K, Dill KA, DiMaio F, Farrell DP, Fraser JS, Herzik MA Jr, Hoh SW, Hou J, Hung LW, Igaev M, Joseph AP, Kihara D, Kumar D, Mittal S, Monastyrskyy B, Olek M, Palmer CM, Patwardhan A, Perez A, Pfab J, Pintilie GD, Richardson JS, Rosenthal PB, Sarkar D, Schäfer LU, Schmid MF, Schröder GF, Shekhar M, Si D, Singharoy A, Terashi G, Terwilliger TC, Vaiana A, Wang L, Wang Z, Wankowicz SA, Williams CJ, Winn M, Wu T, Yu X, Zhang K, Berman HM, Chiu W.
Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge.
Nat Methods. 2021 Feb;18(2):156-164. doi: 10.1038/s41592-020-01051-w. Epub 2021 Feb 4. PMID: 33542514; PMCID: PMC7864804.

Risi C, Schäfer LU, Belknap B, Pepper I, White HD, Schröder GF, Galkin VE.
High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex.
Structure. 2021 Jan 7;29(1):50-60.e4. doi: 10.1016/j.str.2020.09.013. Epub 2020 Oct 15. PMID: 33065066; PMCID: PMC7796959.

Cukkemane A, Becker N, Zielinski M, Frieg B, Lakomek NA, Heise H, Schröder GF, Willbold D, Weiergräber OH.
Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses.
Transl Psychiatry. 2021 Dec 17;11(1):639. doi: 10.1038/s41398-021-01765-1. PMID: 34921141 Free PMC article.