Articles 2025

Resolution of physics and deep learning-based protein engineering filters: A case study with a lipase for industrial substrate hydrolysis.
Gardiner S, Dollinger P, Kovacic F, Pietruszka J, Ess DH, Jaeger K-E, et al. (2025)
PLoS One 20(9): e0332409. https://doi.org/10.1371/ journal.pone.0332409 

Capturing G protein-coupled receptors into native lipid-bilayer nanodiscs using new diisobutylene/maleic acid (DIBMA) copolymers
Ci Chu, Carolyn Vargas, Maria Carolina Barbosa, Simon Sommerhage, Gerald N. Rechberger, David Pahovnik, Ema Zagar, Gunnar F. Schröder, Sandro Keller^,, Manuel Etzkorn
Methods 244 (2025)

Lecanemab Binds to Transgenic Mouse Model-Derived Amyloid-β Fibril Structures Resembling Alzheimer's Disease Type I, Type II and Arctic Folds
F.S. Peralta Reyes, S. Sommerhage, D. Willbold, G.F. Schröder, L. Gremer
Neuropathology and Applied Neurobiology, 2025

Cryo‑EM studies of amyloid‑β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690–695)
Mara Zielinski, Fernanda S. Peralta Reyes, Lothar Gremer, Simon Sommerhage, María Pagnon de la Vega, Christine Röder, Thomas V. Heidler, Stina Syvänen, Dieter Willbold, Dag Sehlin, Martin Ingelsson and Gunnar F. Schröder
Acta Neuropathologica Communications (2025) 13:209 https://doi.org/10.1186/s40478-025-02120-x

Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
Mookyoung Han, Benedikt Frieg, Dirk Matthes, Andrei Leonov, Sergey Ryazanov, Karin Giller, Evgeny Nimerovsky, Marianna Stampolaki, Kai Xue, Kerstin Overkamp, Christian Dienemann, Dietmar Riedel, Armin Giese, Stefan Becker, Bert L. de Groot , Gunnar F. Schröder, Loren B. Andreas & Christian Griesinger
nature communications, October 2025