Computational Structural Biology


The group uses cryo-electron microscopy (cryo-EM) to determine the structure of amyloid proteins. We aim to understand the molecular basis of diseases that involve amyloid aggregation, such as Alzheimer's, Parkinsons's, and diabetes. For this, we study the polymorphism of amyloid fibrils of Aβ, α-synuclein, IAPP, and amyloid model systems such as SH3. Furthermore, the group develops computational methods for modeling and refinement of protein structures using low resolution or sparse experimental data. The focus is on the integration of structure prediction approaches with experimental data from different sources such as single particle cryo-EM, X-ray crystallography and NMR. We are working on the prediction of local structural details using molecular dynamics simulation techniques to improve low-resolution model building and homology modeling. The goal is to reliably describe the structure and conformational dynamics of proteins from low or intermediate resolution data.

Research Topics

  • cryo-electron microscopy
  • amyloids
  • protein structure prediction


Prof. Dr. Gunnar Schröder


Building 05.8v / Room 3029

+49 2461/61-3259


Mara Zielinski

Luisa Schäfer

Simon Sommerhage

Benedikt Frieg

James Geraets

José Camino

Shahrzad Salimi

Jonas Meyer

Duy Tam Vu

Anja Truong

Selected Publications

Last Modified: 31.01.2023