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From Computational Biophysics to Systems Biology

June 6 - 8 2010, Traverse City, Michigan, USA


Systems Biology tries to understand the working of cells from an analysis of the biological networks that describe the interaction and regulation of the various biomolecules. The topology of these networks is usually arrived from protein arrays, DNA chips and other genomic experiments. However, cellular processes are often controlled by transient interactions between proteins that are difficult to determine by experiments. Simulations can complement experiments and trace such interactions, but their use is limited by a lack of interaction between the systems biology community (where in information theoretical approaches dominate) and computational biophysics with its focus on physics- and chemistry- based approaches.

That workshop aimed at overcoming this divide and bringing together researchers from physics, biology, and computer science to acquaint each other with current trends in computational biophysics and systems biology; to explore avenues of cooperation; and to establish together a detailed understanding of cells at a molecular level.

The meeting had its roots in a series of workshops under the same name which had begun in 2006 at the Forschungszentrum Jülich (Germany).

Evolving out of the experience of previous years, the main trust was on:

  • Protein folding and aggregation
  • Nanostructures
  • Multi-protein complexes and supramolecular assemblies
  • Cellular environments and interaction networks